Hepatotoxicity of higher doses of stem bark extracts of Triplochiton scleroxylon in normal rats
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
In this study, stem bark extracts of Triplochiton scleroxylon used as panacea for diabetes mellitus in some parts of Nigeria were examined for hepatotoxic activities.The activities of important liver enzyme markers were investigated periodically in the plasma of experimental rats (Wistar strain) with standard methods involving spectrophotometry while sections of the liver were subjected to appropriate histological examination for tissue structures after 28 days of administration of stem bark extracts. Findings showed that aqueous and ethanolic stem bark extracts of Triplochiton scleroxylon caused significant dose-dependent increases in the activities of plasma alkaline phosphatase (ALP), γ-glutamyl transferase (γ-GT) and alanine aminotransaminase (ALT) relative to normal control (P<0.05). Histological examination reported adverse changes in the liver of test rats with increasing doses of aqueous and ethanolic stem bark extracts beyond 200 mg/kg body weight with the former being safer. Like synthetic drugs, abuse of herbal concoction and decoction could stimulate chronic systemic complications with fatal consequences
Authors and Affiliations
Prof. T. P. Prohp.
Keywords
Related Articles
- EP ID EP518453
- DOI -
- Views 79
- Downloads 0
A Comparative study between Retroperitoneoscopic pyelolithotomy and Percutaneous nephrolithotomy in the management of solitary large renal pelvic calcul
Background: Percutaneous nephrolithotomy (PCNL) is considered gold standard for single large renal pelvic calculi. In this laparoscopic era Retroperitoneoscopic pyelolithotomy (RP) can be considered in selected such pati...
Volvulus of transverse colon
The term volvulus is derived from the Latin word meaning torsion or twisting. Anatomy of the large intestine is very clear. The colon and its mesentery twist, leading to a closed loop colonic obstruction, a more proximal...
Comparative Study of Skin Staples and Polypropylene Sutures for Securing the Mesh in Lichtensein Tension Free Inguinal Hernia Repair
Background: Since time immemorial, inguinal herniorrhaphy is one of the oldest and commonest operations in the surgeon’s technical armamentarium. Since the first true herniorrhaphy was performed by Bassini as early as 18...
Kikuchi Disease Mimicking Tuberculosis: Case Report
Kikuchi-Fujimoto Disease (KFD) is a rare cause of lymphadenopathy due to necrotizing lymphadenitis. It is relevant in Asia; however, many areas in the world report such diagnosis. This disease usually affects females at...
Analysis of Biomarkers (Homocystine/CRP) as Risk Factors for Age-Related Macular Degeneration: A Case Control Study
Introduction: Age Related Macular Degeneration (AMD) is a progressive disorder of the macular area that becomes clinically apparent usually after 50 years of age. When it progresses to advanced stages it can result in se...