Hepatotoxicity Studies of Nimesulide in Litters of Rat
Journal Title: National Journal of Integrated Research in Medicine - Year 2010, Vol 1, Issue 5
Abstract
Present study was carried out to evaluate hepatotoxicity of nimesulide by single dose and seven days administration in sub therapeutic, therapeutic and supra therapeutic doses in litters of rat. Single dose and seven days administration hepatotoxicity studies of nimesulide were carried out in litters of rat of either sex. They were further subdivided into sub therapeutic (20 mg/kg), therapeutic (30 mg/kg) and supra therapeutic (100 mg/kg) groups. Effect of nimesulide on liver functions were analysed by serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and histopathological examination of liver through scoring system. Histopathological changes in liver were observed in therapeutic and supra therapeutic doses in single dose groups and sub therapeutic, therapeutic and supra therapeutic doses in seven days groups. In single dose of nimesulide in litters, there were significant increases in biochemical parameters (p< 0.05) in supratherapeutic doses. However, in seven days studies of nimesulide in litters, there were significant increases in biochemical parameters (p< 0.05) in therapeutic and supratherapeutic doses. The present study indicates that nimesulide causes significant hepatotoxicity in litters of rat.
Authors and Affiliations
Parvati B. Patel, Tejas K. Patel, Sunil Patni, Seema N. Baxi, Hari Om Shrma, C. B. Tripathi
Keywords
Related Articles
- EP ID EP40120
- DOI -
- Views 370
- Downloads 0
Study of Angle of Femoral Torsion in Western Region of India
Background: The femur is thighbone. The angle of femoral torsion is the angle obtaining between the transverse axes of the neck and head that of the lower end of the bone. In the adult, the angle measures about 12 to 1...
Diplopia as an alarm sign in orbital traumatisms
Orbital fractures represent between 10 and 25% of all facial fractures. They may be classified into 3 types: a) orbital rim fractures; b) comminuted fractures of the orbital wall; and c) "trap door" fractures of the orbi...
Sexual Dimorphism of Bicondylar width of Femora
Background: Sexual identification from the skeletal parts is very important medicllegaly as well as anthropologicaly. Present study aims to ascertain values of femoral bicondylar width and to evaluate its possible effi...
‘T.V. Advertisements’ Are These Exploiting the Women
Introduction: The woman is being indecently depicted so extensively in advertisements, that she has become a commodity, a substitute of the product for which she advertises, rather than the featured product. Method: A...
Immunoevaluation and Characterization of Tetanus Toxoid by using Natural polymer as an adjuvant
Natural polymer like potato starch is a mixture of amylose and amylopectin, . Extraction of Potato starch was performed by rasping, centrifugation, refining and drying method. In our research method, we employed potato...