HER-2/NEU EXPRESSION IN STOMACH AND GASTRO-OESOPHAGEAL JUNCTION CARCINOMA IN ENDOSCOPIC BIOPSY SPECIMENS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 88
Abstract
BACKGROUND Prognosis of patients with advanced inoperable carcinoma of stomach and gastro-oesophageal junction remains dismal with palliative chemotherapy. In spite of extensive efforts, the five-year survival rate of these patients worldwide is 20%. The main problem with chemotherapy is its toxicity and thus the management of these patients is very complex. These patients also have associated comorbidities. Therefore, there is a need to understand the molecular biology of these malignancies and develop personalised, specialised and molecular targeted therapy. Hence, we planned this study to evaluate the expression of HER-2/neu in carcinoma of stomach and gastro-oesophageal junction. MATERIALS AND METHODS This was an observational study from January 2010 to December 2016 wherein all cases of carcinoma of stomach and gastrooesophageal junction were retrieved and reviewed. Immunohistochemistry for HER-2/neu protein was done. Statistical analysis was done using SPSS 10.0 windows student version {SPSS Inc., 233 South Wacker Drive, 11th Floor, Chicago, IL 60606-6412}. RESULTS The age of patients varied from 34 to 72 years and mean age was 58.5 years. The common clinical presentation was dyspepsia and regurgitation (82.4%). Of total 85 cases, the grade of HER-2/neu expression was as follows: 0 in 65 (76.47 %) cases, 1+ in 2 (2.3%) cases, 2+ (equivocal) in 4 (4.70 %) cases and 3+ in 14 (16.47 %) cases. CONCLUSION Assessment of HER-2/neu gene amplification by FISH technique and HER-2/neu protein overexpression by immunohistochemistry should be done in all patients with gastric and gastro-oesophageal carcinoma especially inoperable cases so that these patients are treated with molecularly targeted therapy
Authors and Affiliations
Surinder Kumar Atri, Virender Mohan Rana, Vijant Singh Chandial
Keywords
Related Articles
- EP ID EP277892
- DOI 10.14260/jemds/2017/1330
- Views 96
- Downloads 0
CLINICAL ANALYSIS OF LOW VISION AIDS
[b] AIM[/b]: to clinically analyze 50 cases of low vision patients attending tertiary care hospital, their acceptance of low visual aids and to identify common ocular conditions leading to low vision. [b]METHODS[...
SITUS INVERSUS TOTALIS WITH PANCREATIC TAIL ADENOCARCINOMA – A RARE CASE REPORT
Situs inversus is a characterized by the transposition of organs to the opposite side of the body. When associated with dextrocardia, it is known as situs inversus totalis. This condition is rare congenital abn...
COMPARISON OF CLINICAL PRESENTATION AND RISK FACTORS OF STROKE IN DIABETIC VERSUS NON-DIABETIC POPULATION- RESULTS OF A SINGLE CENTRE STUDY
BACKGROUND Objective- To compare clinical presentation and risk factors for the development of stroke in diabetics and non-diabetics population. MATERIALS AND METHODS In this comparative, descriptive study, adult diabeti...
COMPARISON OF THIOPENTONE (1.25%) AND PROPOFOL (1%) FOR INSERTION OF LARYNGEAL MASK AIRWAY IN PAEDIATRIC PATIENTS
BACKGROUND Laryngeal mask airway is widely used in management of paediatric anaesthesia. This study has been designed to investigate whether Propofol 1% alone or Thiopentone along with Halothane is suitable agent for LMA...
ANAESTHETIC MANAGEMENT OF PATIENT WITH GILBERT’S SYNDROME
Gilbert’s syndrome is characterized by mild unconjugated hyperbilirubinemia without either structural liver disease or hemolytic anemia. Bilirubin is produced during the breakdown of hemoglobin and hemoprotei...