HER-2/NEU EXPRESSION IN STOMACH AND GASTRO-OESOPHAGEAL JUNCTION CARCINOMA IN ENDOSCOPIC BIOPSY SPECIMENS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 88
Abstract
BACKGROUND Prognosis of patients with advanced inoperable carcinoma of stomach and gastro-oesophageal junction remains dismal with palliative chemotherapy. In spite of extensive efforts, the five-year survival rate of these patients worldwide is 20%. The main problem with chemotherapy is its toxicity and thus the management of these patients is very complex. These patients also have associated comorbidities. Therefore, there is a need to understand the molecular biology of these malignancies and develop personalised, specialised and molecular targeted therapy. Hence, we planned this study to evaluate the expression of HER-2/neu in carcinoma of stomach and gastro-oesophageal junction. MATERIALS AND METHODS This was an observational study from January 2010 to December 2016 wherein all cases of carcinoma of stomach and gastrooesophageal junction were retrieved and reviewed. Immunohistochemistry for HER-2/neu protein was done. Statistical analysis was done using SPSS 10.0 windows student version {SPSS Inc., 233 South Wacker Drive, 11th Floor, Chicago, IL 60606-6412}. RESULTS The age of patients varied from 34 to 72 years and mean age was 58.5 years. The common clinical presentation was dyspepsia and regurgitation (82.4%). Of total 85 cases, the grade of HER-2/neu expression was as follows: 0 in 65 (76.47 %) cases, 1+ in 2 (2.3%) cases, 2+ (equivocal) in 4 (4.70 %) cases and 3+ in 14 (16.47 %) cases. CONCLUSION Assessment of HER-2/neu gene amplification by FISH technique and HER-2/neu protein overexpression by immunohistochemistry should be done in all patients with gastric and gastro-oesophageal carcinoma especially inoperable cases so that these patients are treated with molecularly targeted therapy
Authors and Affiliations
Surinder Kumar Atri, Virender Mohan Rana, Vijant Singh Chandial
Keywords
Related Articles
- EP ID EP277892
- DOI 10.14260/jemds/2017/1330
- Views 99
- Downloads 0
NEURONAVIGATION-GUIDED VERSUS FLUOROSCOPIC-GUIDED MICRONEUROSURGICAL TRANSSPHENOIDAL PITUITARY SURGERY
BACKGROUND The transsphenoidal route for resection of pituitary adenomas eliminates the need for craniotomy to expose the pituitary gland. It creates narrow access to a deep region of the skull rich with critical neurova...
STUDY OF ANTHROPOMETRIC MEASUREMENTS, BIOCHEMICAL PARAMETERS AND HORMONAL LEVELS IN WOMEN WITH PCOS AT A TERTIARY CENTER OF RURAL HARYANA
BACKGROUND During the past decade, our understanding of pathophysiology of PCOS has undergone a remarkable evolution. Despite our familiarity with this disease, some of its fundamental characteristics remains poorly reco...
DEXAMETHASONE, METOCLOPRAMIDE, AND THEIR COMBINATION FOR THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN FEMALE PATIENTS WITH MODERATE-TO-HIGH RISK FOR PONV UNDERGOING LAPAROSCOPIC SURGERY
BACKGROUND There is evidence that in patients with a high risk of developing Postoperative Nausea and Vomiting (PONV), combination of antiemetics is considered. The aim is to evaluate the effect of prophylactic dexametha...
ENDEMIC OF RHINOSPORIDIOSIS: A CLINICOPATHOLOGICAL PROFILE OF 38 CASES IN A SMALL VILLAGE
Rhinosporidiosis is endemic in various parts of India and Srilanka. We report a total of 38 cases in a single locality from Pavagada situated in northeastern part of Karnataka in South India. All patients presen...
TUBEROUS SCLEROSIS MULTIMODALITY IMAGING UTILITY- A CASE REPORT
PRESENTATION OF CASE A 20 years old female, born of non-consanguineous marriage presented with multiple dome-shaped papules having butterfly or malar distribution. Patient has these facial lesions since 4 - 5 years of ag...