Herbal inhibitors identified for renin and angiotensin converting enzymes by in silico structure based methods
Journal Title: International Journal of Medical and Health Research - Year 2017, Vol 3, Issue 6
Abstract
The enzymes Renin and Aniotensin Converting Enzymes (ACE’s) are key enzymes associated with blood pressure, congestive heart failure and diabetic nephropathy. Renin is a protease, prohormone acting on free floating angiotensinogen. Three kinds of ACE’s namely (ACE, ACE2 ACET (Testicular)) in humans, are carboxy peptidases, membrane bound, one of the receptors of insulin, participating in signal transduction convertsf Angiotensin I to Angiotensin II, a potent vaso constrictor raising blood pressure. This study was proposed with the aim to identify herbal inhibitors for these enzymes. The herbals zinger and Pausinystalia yohimbe were selected as herbal inhibitors, contains alkaloids zingeberene and yohimbine. The 3D structure of the enzymes were predicted using Swiss model server and the target sites identified using Thematics server. The chemical structure of the ligands and peptide structure of the target sequences drawn using Argus lab software and then converted into Protein Data Bank (PDB) format. Finally the targets and ligands were docked using Hex software. Docking results on this ligands indicated that the ligands has a potency to bind to the target sites on the enzymes. The proposed, herbal inhibitors has shown all the desirable features of a potent inhibitor and hence it may be a potential lead compound.
Authors and Affiliations
Sampoornam Balakrishnan, Shila Samuel
Ilaj-bil Tadbeer (Regimental Therapy): A review
Ilaj-Bil Tadbeer or Regimental Therapy is one of the important methods among other methods of treatment in the Unani system of medicine. The other three methods are Ilaj-Bil-Ghiza (Dietotherapy), Ilaj-bil-Dawa (Pharmacot...
Study of troponin-T, troponin-I and CK-MB in acute myocardial infarction
Measuring cardiac biomarkers can be a step toward making a diagnosis for a condition. Whereas cardiac imaging often confirms a diagnosis, simpler and less expensive cardiac biomarker measurements can advise a physician w...
Evaluation of umbilical coiling index as an indicator of perinatal outcome
Both hypocoiled and hypercoiled umbilical cords are associated with adverse perinatal outcome such as intrauterine deaths, preterm delivery, repetitive intrapartum fetal heart deceleration, operative delivery for fetal d...
Risk of developing diabetes in the Indian youth: An evaluation using Indian diabetes risk score (IDRS)
Background: Prevalence of type 2 diabetes mellitus (T2DM) has increased beyond the proposed value in India; hence it is very necessary to screen population to recognize T2DM patients earlier to prevent associated complic...
The study of hepatitis B and hepatitis C infection in patients and healthy blood donors
Introduction:Safe blood and blood products should be offered to all patients in need for blood transfusion. The objectives of the present study were to establish prevalence estimates for hepatitis B and hepatitis C virus...