Herpes Simplex Virus 1&2 Genotyping Characterization and Mycobacterium tuberculosis Complex Detection in Neurological Disorders
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 7
Abstract
Herpes simplex virus (HSV) causes a wide spectrum of clinical manifestations in the central nervous system (CNS) along with Mycobacterium tuberculosis complex (MTC). Current study focuses on the molecular characterization of MTC and HSV1&2 in the cases with neurological disorders. 60 clinical samples with clinical manifestations for neurological disorders were collected, MTC and HSV genotyping. DNA was isolated from all the CSF samples and was used further for molecular characterization. Out of 30 clinical samples, 06 CSF yielded positive amplicon with yielding 123 bp product for MTC infection accounting for 20% while 80% samples were found to be negative. ZN staining was performed for all the cases for CSF as non came positive by microscopy. For HSV genotyping, 02 cases came positive where those were the cases of viral meningitis.
Authors and Affiliations
Bhupender Singh Mingwal, Pallavi Rawat, Mayank Singhal, Narotam Sharma
Keywords
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