Herpes zoster complicating imatinib mesylate for gastrointestinal stromal tumour.
Journal Title: Singapore Medical Journal - Year 2007, Vol 48, Issue 1
Abstract
Varicella zoster virus (VZV) infection is uncommon in patients with gastrointestinalstromal tumour (GIST) and who have not been exposed to extensive radiotherapy and/or high-dose chemotherapy.We report a 56-year-old Nigerian man with GIST who developed VZV infection while on imatinib mesylatetherapy. From August 2003 to November 2005, 64 patients (GIST/CML = 6/58) were enrolled into an ongoingGlivec (imatinib mesylate) international patient-assistance programme therapy for Philadelphia/bcr-abl-positivechronic myeloid leukaemia (CML) and CD117-positive GIST patients at Obafemi Awolowo University TeachingHospitals Complex, Ile-Ife, Nigeria. The patient developed herpes zoster (HZ) infection 23 months intotherapy with Glivec. With his absolute lymphocyte count at 2,774 cells per microlitre and CD4 count at950 cells per microlitre, no obvious immunological defect was observed. Prompt resolution of symptomswithout sequelae was achieved by treating with acyclovir, analgesic and dressing of lesions with desiccant.To our knowledge, this is the first reported case of HZ infection in a patient with GIST on Glivec therapy,and the response is similar to that of CML patients who developed VZV while on similar therapy.
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