HET CAM IRRITANCY STUDY FOR DEVELOPMENT OF GATIFLOXACIN IN SITU GEL FORMULATION.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 5
Abstract
Purpose: Formulation and evaluation of annon irritant ion activated in situ gel of a flouroquinolone antibiotic, Gatifloxacin. Methods: Ion activated in situ gel formulation was developed using Gellan gum as phase transition polymer and HPMC K 100M as release retardant which can undergo a sol-gel transition in the cul-de-sac of the eye. Results:Gatifloxacin in situ gel formulation with pH 6.0-6.3 and 52 cps in solution form resulted in gel formation in simulated lacrimal fluid having 325 cps viscosity, indicating phase transition behaviour in physiological conditions of eye. It was found to be isotonic, as it exhibited no change in the size and shape of RBCs. Formulation was found to be non irritant to eyes exhibiting mean score of zero in HET-CAM (Hen?s Egg Test ChorioAllantoic Membrane) test for ocular irritancy for 5 min Conclusion: It can be concluded that the developed in situ gel formulation can be viewed as a better alternative to the conventional eye drops of Gatifloxacin by virtue of its ability to enhance pre corneal residence time and consequently ocular bioavailability with lesser frequency of administration.
Authors and Affiliations
Ankita Kapoor And G. D Gupta.
Keywords
Related Articles
- EP ID EP601247
- DOI 10.21474/IJAR01/9154
- Views 71
- Downloads 0
CLINICAL EVALUATION OF ROLE OF AMRUTADYA TAILA MATRA BASTI IN THE MANAGEMENT OF VATARAKTA: A CASE STUDY.
Vatarakta is a disease related with Khavaigunya found in RaktavahaSrotas which includes vitiated Vata and blood. Small joints of feet and hands are mainly affected in Vatarakta. Vata being pre dominant among the Tridosha...
SOCIAL ROLE OF MILITARY?S WIFE IN ORDER TO SUPPORT HUSBAND PROFESSIONALISM AS THE NATIONAL DEFENCE VANGUARD (CASE STUDY OF KARTIKA CHANDRA KIRANA NATIONAL ARMED WIVES\' UNION (PERSIT) AT LIV YONARHANUDSE-8 PD V BRAWIJAYA).
The purpose of this research is to: 1) Analyze characteristics of the Kartika Chandra Kirana National Armed Wives Union member at Liv Yonarhanudse-8 Pd V Brawijaya on the assessment of social support for husbands, 2) Ana...
A CONCEPTUAL FRAMEWORK FOR IMPLEMENTING TQM IN THE PRIMARY HEALTHCARE CENTERS AND EXAMINING ITS IMPACT ON PATIENT SATISFACTION.
Purpose? the purpose of this paper is to assess the level of implementing total quality management (TQM) in the accredited primary healthcare centers in Dubai and investigate the relationship between TQM practices and pa...
LES D?TERMINANTS DE L?ACCEPTATION DES TIC PAR LES DIRIGEANTS DES STRUCTURES D?H?BERGEMENT RURALES DE LA R?GION DE SOUSS MASSA AU MAROC: TEST DU MOD?LE TAM3 ETENDU.
Depuis plusieurs ann?es, les Technologies de l?Information et de la Communication (TIC) se sont diffus?es tr?s largement dans l?ensemble des secteurs d?activit? et des organisations, notamment avec la baisse des co?ts d?...
OPTIMIZATION OF THE SIZING OF HYBRID WIND, SOLAR PHOTOVOLTAIC, BIODIESEL AND STORAGE SYSTEMS USING THE INTEGER LINEAR PROGRAMMING METHOD.
This article presents a program for optimizing the sizing of hybrid energy systems, composed of wind turbines, photovoltaic modules and biodiesel generators, with battery storage, for the electrification of isolated site...