HETERO-BINUCLEAR COMPLEXES OF LANTHANUM (III) USING BRIDGING N,N?-BIS(2-PYRIDYLMETHYL)OXAMIDE AND TERMINAL 1,10-PHENANTHROLINE: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 6
Abstract
In the present study, hetero-binuclear La(III) complexes were newly synthesized using well known bridging ligand N,N′-bis(2-pyridylmethyl)oxamide (2PMO, 1) and “complexes as ligands” [Cu(2PMO)] (2) and [Ni(2PMO)] (3). The newly synthesized mononuclear (4) as well as hetero-binuclear complexes (5 and 6) were characterized by analytical and spectroscopic techniques. The newly synthesized complexes were tested for their binding ability towards CT-DNA and chemical nuclease property towards SC pUC 19 DNA. The complexes were tested for antibacterial activities against Gram negative bacteria (E. coli and K. pneumonia) and Gram positive bacteria (B. subtilis and S. aureus), antioxidant activities by DPPH radical scavenging and ferrous-ion chelation methods and cytotoxicity against MCF-7 cell lines by MTT assay. The structure-activity relationship revealed that the newly synthesized hetero-binuclear complexes show potent DNA binding and chemical nuclease activities, antibacterial, antioxidant and cytotoxic activities.
Authors and Affiliations
P. R. Chetana, Vibha Vinayakumar Bhat, Mohan A. Dhale
Keywords
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- EP ID EP622233
- DOI 10.25004/IJPSDR.2018.100606
- Views 61
- Downloads 0
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