High-dose cytarabine-associated cerebellar toxicity: A case report
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 1
Abstract
High-dose arabinoside cytarabine is used as an effective regimen for post-remission acute leukemia and refractory leukemia treatment. Most commonly used regimen is 3 g/m2 IV over 1-3 h q12 h for a total of 8-12 doses. Major toxic effects associated with cytarabine are related to bone marrow, gastrointestinal tract, and nervous system. Acute cerebellar toxicity with ataxia and dysarthria is well-known adverse effect during high-dose cytarabine therapy. This case report describes about a patient with acute myeloid leukemia on high-dose cytarabine who developed ataxia and left-sided nystagmus as cerebellar toxicity. These symptoms persisted till 2 days after the termination of high-dose cytarabine the gradually improved with steroids. Patient’s good response to methyl prednisolone illustrates immune-mediated mechanism of neurotoxicity.
Authors and Affiliations
Delcey Reachel Varghese, Dawnwin Joseph, Raghuveer Prabhu, Anila K N
Keywords
Related Articles
- EP ID EP450363
- DOI 10.5455/njppp.2018.8.0724818072017
- Views 63
- Downloads 0
Status of inflammatory markers and growth factor in gastric ulcer protective effects of Punica granatum L. peel extract in rat
Background: Inflammatory markers, namely, myeloperoxidase (MPO), cytokines (tumor necrosis factor-alpha [TNF-α], and interleukin-1 beta [IL-1β]) and vascular endothelial growth factor (VEGF) have been reported to play an...
Effect of 12 weeks of slow breathing exercise practice on anthropometric parameters in healthy volunteers
Background: Regular practice of slow breathing technique shows improvement in the cardiorespiratory functions. The previous studies have reported that it is well known to decrease the effect of stress which, in turn, imp...
Comparison of effect of aspartame (artificial sweetener) and aspartame-sweetened diet drink on autonomic reactivity of volunteers
Background: Obesity is the single most important risk factor in the onset of various diseases. Dieting is considered as an important part of today’s daily life; the aim of our study is to explore the effects of aspartame...
Influence of nutrition and socioeconomic status on intellectual development in school children
Background: The nutritional adequacy is one of the determinants of quality of human resources everywhere. Malnutrition is the root cause for the death of 6 million children each year in developing countries. Nutri...
Comparison of residual styrene monomer determination of pharmaceutical materials packed with polystyrene using gas chromatography and ultraviolet/visible spectrophotometer
Background: Plastics such as plastic wrapping are an integral part of today’s society. Plastics are made by polymerization of styrene monomers. If the polymerization reaction is not perfect, then there will be unreacted...