High-dose cytarabine-associated cerebellar toxicity: A case report
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 1
Abstract
High-dose arabinoside cytarabine is used as an effective regimen for post-remission acute leukemia and refractory leukemia treatment. Most commonly used regimen is 3 g/m2 IV over 1-3 h q12 h for a total of 8-12 doses. Major toxic effects associated with cytarabine are related to bone marrow, gastrointestinal tract, and nervous system. Acute cerebellar toxicity with ataxia and dysarthria is well-known adverse effect during high-dose cytarabine therapy. This case report describes about a patient with acute myeloid leukemia on high-dose cytarabine who developed ataxia and left-sided nystagmus as cerebellar toxicity. These symptoms persisted till 2 days after the termination of high-dose cytarabine the gradually improved with steroids. Patient’s good response to methyl prednisolone illustrates immune-mediated mechanism of neurotoxicity.
Authors and Affiliations
Delcey Reachel Varghese, Dawnwin Joseph, Raghuveer Prabhu, Anila K N
Keywords
Related Articles
- EP ID EP450363
- DOI 10.5455/njppp.2018.8.0724818072017
- Views 68
- Downloads 0
The activity of metabolic enzymes in the saliva of lung cancer patients
Background: So far, optimization problems for diagnostics and prognostication aids have been still relevant for lung cancer as a leader in the structure of cancers. Aims and Objectives: A search for regularities of chang...
A regional hemovigilance study of transfusion-related adverse events at a tertiary care hospital
Background: Blood transfusion is a routine, life-saving medical intervention which is generally regarded as safe when done appropriately. Hemovigilance is systemic surveillance of adverse transfusion reactions (ATRs). Ai...
Study of relationship between anthropometric parameters and heart rate-corrected QT interval (QTc) in normal body mass index Indian males with abdominal obesity
Background: Abdominal obesity is seen with increased prevalence in South Asians even among those who have a body mass index (BMI) <25 kg/m2 . Increasing intra-abdominal deposition of fat is closely associated with prolon...
Evaluation of summative assessment pattern for undergraduate pharmacology practical examination
Background: The Medical Council of India (MCI) has stated the minimum standards in its regulations for the quality of Medical Education in India. It is observed that assessment of medical students, though an important as...
Normative data of peak expiratory flow rate in healthy school children of Ghaziabad city—a pilot study
Background: Age, sex, weight, and height are the main factors that affect peak expiratory flow rate (PEFR). Various authors have shown that geographical, climatic, anthropometric, nutritional, and socioeconomic co...