High Dose Oseltamivir Induced Hypothermia and Respiratory Suppression in Elderly: A Case Report
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2017, Vol 9, Issue 4
Abstract
Introduction: Oseltamivir is an antiviral drug, used for influenza treatment. Neurological side effects of this drug, including hypothermia and respiratory arrest, were demonstrated in animal models. Case Presentation: We reported a case of an elderly male who presented with influenza B pneumonia and respiratory failure. He received high dose and extended duration of Oseltamivir. He developed hypothermia and central hypoventilation, complicated with prolonged weaning. At that time, there were no sedative and neuromuscular blocking agents, and no evidence of brain stem dysfunction and endocrine crisis. Concerning of rare reported adverse reactions of Oseltamivir in animal models, this drug was discontinued. Consequently, his symptoms improved and he was successfully liberated from mechanical ventilation. Conclusion: We hereby report a case of Oseltamivir associated respiratory suppression and hypothermia in human.
Authors and Affiliations
Metinee Tangnantawiwat, Napplika Kongpolprom
Keywords
Related Articles
- EP ID EP309714
- DOI 10.9734/IJMPCR/2017/34781
- Views 95
- Downloads 0
Low Residue Diet & Codeine May Substitute Faecal Diversion in Conservative Management of Patient with Rectourethral Fistula - A Case Report
Aims: We present a patient that developed rectourethral fistula following prostatectomy for a misdiagnosed prostate cancer. He was managed conservatively without faecal diversion. Case Presentation: A 65 year old man pr...
Urinary Obstruction Due to Fungal Infection in Two Preterm Siblings
Extravasation of urine and formation of urinoma is rare in the absence of either trauma or congenital anomalies. Fungal ball formation in urinary tract can cause obstruction leading to extravasation. We present two such...
An Erupted Compound Composite Odontoma Associated with Supernumerary Tooth
Though odontomas are one of the common odontogenic tumors, erupted odontomas are rare. Erupted odontomas may cause disturbance to the developing occlusion like impaction of the underlying teeth, ectopic eruption or displ...
Clinical Course of a Case with Sarcomatoid Renal Cell Carcinoma
Introduction: Renal cell carcinoma (RCC) is the most frequently observed malign neoplasm of the kidney. Its sarcomatoid variant (SRCC) is rare but aggressive. Our aim is to present the clinical course of a 51 year-old pa...
Seven Year Survival After Multiple Recurrences and Repeated Metastasectomies with Targeted Therapies for Renal Cell Carcinoma
Background: In spite of resistance and limited response to chemotherapy, radiotherapy and immunotherapy, recent advances led to several targeted agents that showed the prolongation of progressive free survival. Due to th...