High Dose Oseltamivir Induced Hypothermia and Respiratory Suppression in Elderly: A Case Report
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2017, Vol 9, Issue 4
Abstract
Introduction: Oseltamivir is an antiviral drug, used for influenza treatment. Neurological side effects of this drug, including hypothermia and respiratory arrest, were demonstrated in animal models. Case Presentation: We reported a case of an elderly male who presented with influenza B pneumonia and respiratory failure. He received high dose and extended duration of Oseltamivir. He developed hypothermia and central hypoventilation, complicated with prolonged weaning. At that time, there were no sedative and neuromuscular blocking agents, and no evidence of brain stem dysfunction and endocrine crisis. Concerning of rare reported adverse reactions of Oseltamivir in animal models, this drug was discontinued. Consequently, his symptoms improved and he was successfully liberated from mechanical ventilation. Conclusion: We hereby report a case of Oseltamivir associated respiratory suppression and hypothermia in human.
Authors and Affiliations
Metinee Tangnantawiwat, Napplika Kongpolprom
Keywords
Related Articles
- EP ID EP309714
- DOI 10.9734/IJMPCR/2017/34781
- Views 73
- Downloads 0
Presence of Endocarditis on the Patch in the Left Ventricular Outflow Tract Successful Treated with Daptomycin
We present a rare case of endocartitis on the patch in the left ventricular outflow, in a 42 year-old man patient that had undergone surgical correction of tetralogy of Fallot and definitive closure with Dacron patch of...
Unusual Cause of Rhabdomyolysis Causing Acute Renal Failure: Achillea millefolium and
Introduction: Rhabdomyolysis is a frequent disorder resulting from many different causes which may be apparent from the history, e.g. trauma, heavy exercise, intoxications. It contains both clinical and biochemical compo...
Osteoporosis Reduction in Pre and Postmenopausal Women Using a High Intensity Exercise Program
Aim: This manuscript describes how a weekly high intensity weight lifting exercise regimen was able to improve the osteoporotic state in women with a previous diagnosis of low bone mineral density. Case Presentation: Thi...
Synchronous Thyroid and Gastric Mantle Cell Lymphoma
Introduction: Mantle cell lymphoma (MCL) is a distinct entity within the World Health Organization classification of lymphoid neoplasm and represents approximately 8% of lymphoma. Patients with mantle-cell lymphoma typic...
A Case of Gastric and Esophageal Perforation Caused by Endoscopic Retrograde Cholangiopancreatography
Aim: Endoscopic retrograde cholangiopancreatography (ERCP) is no longer in use as a diagnostic procedure but rather when a therapeutic intervention is needed or most likely to be needed depending on the pre-ERCP imagings...