High Expression of Mir-21 in Tissue Correlated with the Poor Survival of Patients with Esophageal Cancer: A Pilot Study Using the Meta-Analysis
Journal Title: Journal of Preventive Medicine and Care - Year 2015, Vol 1, Issue 1
Abstract
Objective: MicroRNAs are involved in the onset, progression and dissemination of esophageal cancer, and they may be useful as prognostic biomarkers. This study aims to evaluate the relation of miR-21 expression and the prognosis of esophageal cancer patients. Methods: In this study, a meta-analysis is performed by searching PubMed, Science Direct databases, and Cochrane Library. Data are extracted from studies evaluating survival of esophageal cancer patients with either high or low miR-21 expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) are calculated. Results: A total of 579 cases of esophageal cancer from five studies are involved for this global meta-analysis. The HR of survival of patients with high miR-21 expression is 1.47 (95% CI: 1.12–1.91; p<0.01) as compared with those with low expression. Conclusions: miR-21 may be a predictor for survival of esophageal cancer patients.
Authors and Affiliations
Wei Zhou, Xin Zhou, Jin-qiang Liu, Yu-jie Zhang, Liu Hong
Keywords
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- EP ID EP333716
- DOI 10.14302/issn.2474-3585.jpmc-15-757
- Views 141
- Downloads 0
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