High-fat Diet Alone or Combined with Stress Impaired Glucose Tolerance in Female Rats
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 7, Issue 4
Abstract
Background: According to the role of estrogens in metabolic responses to high-fat diet and/or stress, this study aimed to investigate the effect of high- cow intra-abdominal fat diet either alone or combined with acute foot-shock stress on glucose metabolism at proestrus and diestrus phases of estrous cycle. Material and Methods: Female rats were divided into high-fat and normal diet groups. The diet groups recruited into control and stressed and finally subdivided into proestrus and diestrus groups. Stress was applied by a communication box. Blood samples were taken after stress exposure to determine glucose related parameters, and then glucose tolerance test was performed. Moreover, homeostasis model assessment of insulin resistance (HOMA-IR) index, body weight, food intake, abdominal fat and adrenal gland weights were evaluated. Results: High-fat diet did not change body weight but decreased food intake and increased energy intake. Moreover, the intra-abdominal fat weight and plasma leptin concentration were increased by applying high-fat diet. In addition, high-fat food consumption caused a decrease in plasma estradiol concentration and an increase in plasma corticosterone level (following stress exposure) in proestrus phase. High-fat diet either alone or combined with stress impaired glucose tolerance at proestrus phase. However, did not affect fasting plasma glucose and insulin levels as well as HOMA-IR index. Conclusion: The results showed that the high-fat diet used in this study, alone or combined with stress, impaired glucose homeostasis in female rats. However, the proestrus phase compared with diestrus phase was more sensitive to the aforementioned environmental interventions.
Authors and Affiliations
Hamid Vasfi, Fatemeh Rostamkhani, Mina Salimi, Homeira Zardooz
Keywords
Related Articles
- EP ID EP353548
- DOI 10.9734/ARRB/2015/18905
- Views 107
- Downloads 0
Primary and Secondary Humoural Immune Response to Anti-Rabies Vaccination in Dogs Experimentally Infected with Single Trypanosoma brucei and Trypanosoma congolense Infections and Treatment with Diminazene Aceturate
Trypanosomosis is a disease that causes extensive physiopathological effect in the blood and tissues which may affect normal immune response in the infected host. The condition is exacerbated by the seeming existence of...
Influence of Treatment Parameters on Symptom Relief in Individuals with Vitamin B12 Deficiency
Objective: Ever-growing numbers of displeased vitamin B12 deficiency patients are joining online support groups seeking help. The current study attempted to assess, quantitatively, several of the concerns of these patien...
Salinity Induced Longitudinal Zonation of Polychaete Fauna on the Bonny River Estuary
The longitudinal zonation of polychaetes was studied across 13 stations on the Bonny River estuary. A total of eighty-eight (88) species of polychaetes, from 68 genera, belonging to 31 families, were identified. Based on...
A Renewed Understanding of Shell-shape Diversity among Marine Gastropod Species: Invariance and Covariance between Geometrical Parameters in Conispirally Coiled Shells
Approximately conispirally coiled shells make the bulk of shell structure among marine gastropod species, apart from those shells with strongly overlapping whorls (typical, in particular, of Cones, Cowries and the like)....
Interference by Human Anti-mouse Antibodies in Immunoassays: Falsely Elevated Cardiac Troponins Leading to Negative Coronary Angiograms
Cardiac Troponins are an extremely important indicator of myocardial injury and American College of Cardiology (ACC) and American Heart Association (AHA) guidelines include Cardiac Troponins as one of the major diagnosti...