High immunoexpression of progesterone-induced blocking factor (PIBF) in endometrial cancer
Journal Title: European Journal of Gynaecological Oncology - Year 2019, Vol 40, Issue 1
Abstract
Purpose of Investigation: This study aims to investigate PIBF expression levels in normal, hyperplastic, and endometrioid adenocarcinoma paraffin blocks. The purpose of this study is to determine the PIBF expression levels in endometrial cancer cells. Materials and Methods: A total of 90 patients were investigated. Thirty of those were diagnosed as having normal endometrial tissue, 30 had endometrial hyperplasia, and 30 had endometrioid adenocarcinoma. The expression of PIBF was assessed using immunohistochemically using paraffin-embedded tissue blocks. Results: Tissue sections were compared based on immunostaining with PIBF. The authors detected higher stromal PIBF expression in the endometrioid adenocarcinoma group as compared to the endometrial hyperplasia and normal endometrium groups (p < 0.001). The glandular PIBF expression did not differ among the groups (p > 0.05). Conclusions: Endometrial cancer cells have higher levels of expression of PIBF protein than normal endometrial tissue and endometrial hyperplasia tissue based on immunohistochemistry staining. PIBF immunostaining may be helpful in preoperatively differentiating between atypical endometrial hyperplasia (AEH) and endometrioid adenocarcinoma (EC) in suspicious cases.
Authors and Affiliations
E. Sahin, Y. Madendag, M.E. Sahin, I. C. Madendag, A. T. Tayyar, F. Senel, H. Karaman, G. Acmaz
Keywords
Related Articles
- EP ID EP663033
- DOI 10.12892/ejgo4338.2019
- Views 75
- Downloads 0
The pleiotropic factor Y-box binding protein-1 enhances the anti-proliferative efficacy of 4-hydroxytamoxifen and fulvestrant on breast cancer cells in vitro
Purpose of investigation: The pleiotropic factor Y-box binding protein-1 (YB-1) is clinically correlated with breast cancer patients’ poor outcome. Due to the intereference of YB-1 with the estrogen receptor, the authors...
Plasma fibrinogen, CRP, and hs-CRP levels in patients with benign and borderline ovarian tumours
Objective: Ovarian tumours can be classified as benign, borderline or malignant lesions. The purpose of this study was to assess, inter alia, fibrinogen concentration, and the (C-reactive proteins) and high-sensitivity C...
Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines
Purpose of Investigation: Patients suffering from ovarian cancer often use mistletoe preparations in combination with Taraxacum officinale (dandelion) extracts as supplementary therapy to conventional medicine. However,...
Clinical features and prognostic factors associated with malignant transformation of ovarian mature cystic teratoma
Purpose: To explore the clinical characteristics and identify potential prognostic factors associated with malignant transformation (MT) of ovarian mature cystic teratoma (MCT). Materials and Methods: This study analyzed...
High immunoexpression of progesterone-induced blocking factor (PIBF) in endometrial cancer
Purpose of Investigation: This study aims to investigate PIBF expression levels in normal, hyperplastic, and endometrioid adenocarcinoma paraffin blocks. The purpose of this study is to determine the PIBF expression leve...