High-level resistance to aminoglycoside, vancomycin, and linezolid in enterococci strains
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2013, Vol 3, Issue 3
Abstract
Objective: This study aimed to identify antibiotic susceptibility rates of enterococcal strains, and to compare the highlevel resistance to aminoglycosides (HLAR) in vancomycin-sensitive enterococcal species (VSE) and vancomycin-resistant enterococcal species (VRE). Methods: The study included 100 VRE and 100 VSE strains recovered from the samples sent to laboratory from various departments of Haydarpaşa Numune Training and Research Hospital. Results: All VRE strains were defined as Enterococcus faecium, although of the VSE strains, 53% were identified to be as Enterococcus faecalis, 42% E. faecium, 3% Enterococcus durans, and 2% Enterococcus avium. High-level resistance to vancomycin (MIC, >256 μg/ml) was determined in all VRE strains and when analyzing MIC values for teicoplanin, five strains were found to be moderately susceptible (MIC, 16 μg/ml) and 95 strains were resistant (MIC, >32 μg/ml). Of the VRE strains, one was linezolid-resistant (MIC, 12 μg/ml) and the other was intermediately susceptible (MIC, 4 μg/ml) and remainders were evaluated to be susceptible (MIC, <2 μg/ml). In VRE strains, high-level gentamicin resistance (HLGR) was found to be 83% and high-level streptomycin resistance (HLSR) 89%, association of HLSR with HLGR was 78%. In VSE strains, HLGR was found to be 42% and, HLSR 48%, the association of HLSR with HLGR was found to be 36%. HLAR in VRE strains was found to be higher as compared with VSE strains (p <0.005). Conclusion: Antimicrobial resistance is increasing in enterococci strains. Therefore a follow-up is required resistance pattern including both vancomycin resistance and HLAR. J Microbiol Infect Dis 2013; 3(3): 100-103 Key words: Enterococcus spp. , vancomycin, linezolid, aminoglycoside, resistance
Authors and Affiliations
Gülçin Baldır, Derya Engin, Metin Küçükercan, Asuman İnan, Seniha Akçay, Seyfi Özyürek, Sebahat Aksaray
Keywords
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- EP ID EP156921
- DOI 10.5799/ahinjs.02.2013.03.0090
- Views 114
- Downloads 0
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