High prevalence of mupirocin resistance in methicillin resistant staphylococci and its clinical significance
Journal Title: International Journal of Orthopaedics Sciences - Year 2018, Vol 4, Issue 3
Abstract
Background: With the increasing pressure to prevent MRSA infections, it is possible that there will be increased use of Mupirocin for nasal decolonization of MRSA. Mupirocin is bacteriostatic at low concentration near the MIC for staphylococcus aureus but it is bactericidal at concentrations achieved by topical administration (20,000ug/ml) with the 2% formulation. Earlier reported High level Mupirocin resistance strain is associated with decolonization failure. The present study was carried out to determine the rates of high level and low level Mupirocin resistance (MuH and MuL) in methicillin resistant Staphylococcus aureus and methicillin resistant coagulase negative staphylococci. Materials and methods: A prospective study was carried out on 104 non-duplicate Staphylococcal isolates from various clinical specimens were tested for Mupirocin resistance using 5µg and 200µg discs. Detection of Mupirocin resistance was done by the disk diffusion method using 5 μg and 200 μg Mupirocin disks to determine low- and high-level resistance, respectively. Results: Mupirocin resistance was 7.8%, and 4.6% in MRSA and 40% and 20% in MR-CONS for 5 µg and 200 µg disc respectively. Conclusion: Institutions that are considering the implementation of widespread Mupirocin use should consider these resistance issues and develop strategies to monitor the impact of Mupirocin use. Perioperative prophylaxis with nasal mupirocin therapy (PPNMT) can reduce the incidence of MRSA SSls after orthopaedic surgery, probably by reducing nasal MRSA carriage in the endemic setting, without selecting for mupirocin resistance.
Authors and Affiliations
C Palani Kumar, KM Mohana Soundaram, R Arbind Kumar Choudhary
Keywords
Related Articles
- EP ID EP487657
- DOI 10.22271/ortho.2018.v4.i3h.80
- Views 122
- Downloads 0
Clinical study of outcome of unstable intertrochanteric fracture treated by proximal femoral nail: A prospective study
Background: The AO/ASIF proximal femoral nail (PFN) is a new device designed for the treatment of the unstable intertrochanteric femoral fracture. The purpose of this study to find the outcome of such fractures treated b...
Treatment of displaced lateral clavicular fractures with hook plate, a retrospective review
Fractures of the clavicle have been treated historically by conservative means. However lateral end fractures of clavicle are known to be unstable due to injury to the coracoclavicular ligaments. Hook plate has been used...
A comparative study of functional outcomes of surgical versus conservative management of diaphyseal fractures of tibia in children
Introduction: Tibia Shaft Fractures in children are very common. Despite newer innovations in implants and techniques no standardize management stratergy is available. Aims and Objectives: To compare and study time for u...
Functional outcome of management of infected nonunion of humerus by limb reconstruction system (LRS)
Introduction: The infected non-union of humerus resulting from surgical intervention to achieve bone healing are very difficult to manage by traditional methods. Materials & methods: We treated 20 infected non-union of d...
Study of functional and radiological outcome of total knee arthroplasty using the knee society score
The common causes of arthritis of the knee include Osteoarthritis (OA), Rheumatoid Arthritis (RA), Juvenile Rheumatoid Arthritis, Post traumatic Arthritis or secondary Osteoarthritis and other types of inflammatory arthr...