High-throughput scaffold-free microtissues through 3D printing
Journal Title: 3D Printing in Medicine - Year 2018, Vol 4, Issue
Abstract
Three-dimensional (3D) cell cultures and 3D bioprinting have recently gained attention based on their multiple advantages over two-dimensional (2D) cell cultures, which have less translational potential to recapitulate human physiology. 3D scaffold supports, cell aggregate systems and hydrogels have been shown to accurately mimic native tissues and support more relevant cell-cell interactions for studying effects of drugs and bioactive agents on cells in 3D. The development of cost-effective, high-throughput and scaffold-free microtissue assays remains challenging. In the present study, consumer grade 3D printing was examined as a fabrication method for creation of high-throughput scaffold-free 3D spheroidal microtissues.
Authors and Affiliations
Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander
Keywords
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- EP ID EP680693
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