Highly asymmetric aldol reaction of cyclohexanone and aromatic aldehydes catalyzed by bifunctional cyclohexane derived thiourea organocatalyst
Journal Title: Asian Journal of Green Chemistry - Year 2019, Vol 3, Issue 2
Abstract
Novel two L-proline analogues as thiourea organocatalysts were synthesised, first is the assembly of a structurally well-defined cyclohexane scaffold with a thiourea moieties and amine functionalities could constitute a new class of organocatalysts. Second is the triazole-3-thione analogue. The first one found to be efficient catalysts for the direct asymmetric aldol reaction between ketone and aromatic aldehydes. The catalysts exhibited high catalytic activity, diastereoselectivity and excellent enantioselectivity at room temperature with a low loading.
Authors and Affiliations
Hanmant M. Kasralikar, Suresh C. Jadhavar, Sudhakar R. Bhusare
Keywords
Related Articles
- EP ID EP468910
- DOI 10.22034/ajgc.2018.141271.1086
- Views 98
- Downloads 0
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