Highly efficient and rapid synthesis of diverse hydantoin derivatives using nano-ordered ZnO catalyst under mechanochemical ball milling
Journal Title: Iranian Chemical Communication - Year 2017, Vol 5, Issue 1
Abstract
A mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. A multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. The proposed optimized reaction conditions ,i.e. solvent-free conditions under ambient temperature in the presence of low amount of ZnOnano-catalyst, were very efficient resulting in the formation of the desired products with good to excellent yields. Furthermore, the presented methodology is in accord with green chemistry principles. Keywords: Bucherer-Bergs; hydantoin derivatives; multicomponent reactions (MCRs); green chemistry.
Authors and Affiliations
Bozorg Maddah
Keywords
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