Histamine in regulation of bone remodeling processes
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Bone remodeling is under autocrine, paracrine, endocrine and central nervous system control. One of the potential endogenous factors affecting bone remodeling is histamine, an endogenous amine which acts as a mediator of allergic reactions and neuromediator, and induces production of gastric acid. Histamine H1 receptor antagonists are widely used in the treatment of allergic conditions, H2 receptor antagonists in peptic ulcer disease, and betahistine (an H3 receptor antagonist and H1 receptor agonist) is used in the treatment of Ménière’s disease.Excess histamine release in mastocytosis and allergic diseases may lead to development of osteoporosis. Clinical and population-based studies on the effects of histamine receptor antagonists on the skeletal system have not delivered unequivocal results.Expression of mRNA of histamine receptors has been discovered in bone cells (osteoblasts and osteoclasts). Histamine synthesis has been demonstrated in osteoclast precursors. Histamine increases bone resorption both by direct effects on osteoclast precursors and osteoclasts, and indirectly, by increasing the expression of RANKL in osteoblasts. In in vivo studies, H1 and H2 receptor antagonists exerted protective effects on the bone tissue, although not in all experimental models. In the present article, in vitro and in vivo studies conducted so far, concerning the effects of histamine and drugs modifying its activity on the skeletal system, have been reviewed.
Authors and Affiliations
Marek Wiercigroch, Joanna Folwarczna
Keywords
Related Articles
- EP ID EP67029
- DOI -
- Views 127
- Downloads 0
Flawiwirusy – nowe patogeny chorobotwórcze dla ludzi
Rodzina Flaviviridae obejmuje wirusy przenoszone przez stawonogi, takie jak komary i kleszcze. Opisano już ponad 100 gatunków należących do rodziny Flaviviridae, z których większość jest patogenami zwierząt, choć nie moż...
Częstość stosowania leczenia biologicznego na Dolnym Śląsku u chorych z reumatoidalnym zapaleniem stawów i zesztywniającym zapaleniem stawów kręgosłupa
Methylprednisolone– acute spinal cord injury, benefits or risks?
Methylprednisolone is a synthetic glucocorticoid with a potent and long-acting anti-inflammatory, antiallergic and immunosuppressant. Its mechanism of action of methylprednisolone is the result of many cellular changes....
Mobile antibiotic resistance – the spread of genes determining the resistance of bacteria through food products
In recent years, more and more antibiotics have become ineffective in the treatment of bacterial nfections. The acquisition of antibiotic resistance by bacteria is associated with circulation of genes in the environment....
The correlations between aging of the human body, oxidative stress and reduced efficiency of repair systems
The article presents an current knowledge overview about the importance of oxidative stress and reduced efficiency of repair processes during the aging process of the human body. Oxidative damage to cellular macromolecul...