Histofunctional status of kidney in patients with rheumatoid arthritis
Journal Title: Dicle Tıp Dergisi - Year 2011, Vol 38, Issue 4
Abstract
Objectives: The aim of this study was to observe the effects of duration and severity of disease on renal functions and histopathology in patients with rheumatoid arthritis (RA). Material and methods: The study included 50 patients of RA, who were divided into two groups of 25 patients each. Disease severity was assessed by Disability Activity Score (DAS). The renal parameters i.e., urine complete examination, blood urea, serum creatinine and creatinine clearance were estimated at enrolment. Percutaneous renal biopsy was performed in patients having active urinary sediment, haematuria and/or proteinuria more than 300 mg/day and serum creatinine more than 1.5 mg/ml. Results: Group I patients had duration of disease between 2-5 years and in Group II the duration was more than 5 years. Urine abnormalities were documented in 28% RA patients and 12% patients had isolated hematuria, 10% patients presented with isolated proteinurea and combined haematuria and proteinurea was present in 6% patients.14% patients presented with raised creatinine( >1.5mg/ml). Renal biopsy was performed in 20% of patients which showed mesangial glomerulonephritis, membranous glomerulonephritis, secondary amyloidosis and interstitial nephritis. In group I severe DAS score was present in 17% of the patient having urinary abnormality, however 20% patients showed histopathological findings. In group II 63% of patients with severe DAS score had urinary abnormality, 83% showed raised serum creatinine and 60% had histopathological abnormalities indicating severe DAS score and increased duration of disease was associated with significant effects on histofunctional status of kidney. Conclusion: There was a significant increase in renal dysfunction with duration and severity of disease in rheumatoid arthritis.
Authors and Affiliations
Hari Aggarwal, Harpreet Singh, Deepak Jain, Teena Bansal, Promil Jain, Joginder Duhan
Keywords
Related Articles
- EP ID EP92301
- DOI -
- Views 139
- Downloads 0
Febril konvülziyonlu çocuklarda klinik ve paraklinik özellikler
Amaç: Febril konvülziyon ile başvuran hastalarda yaklaşım, tanısal incelemeler, izlem ve tedavi halen tartışmalıdır. Bu çalışmada febril konvülziyon nedeniyle başvuran hastaların klinik özellikleri, laboratuvar, elekt...
C-reactive protein level and obesity as cardiovascular risk factors in polycystic ovary syndrome
tive: To investigate the role of C-reactive protein (CRP) level elevation and obesity for the increased cardiovascular disease risk in polycystic ovary syndrome (PCOS). Methods: A hundred and nine patients wit...
Derin ven trombozu sonrası asemptomatik pulmoner emboli tanısında ventilasyon/perfüzyon sintigrafisi ve multidedektör bilgisayarlı tomografinin karşılaştırılması
Amaç: Pulmoner tromboemboli (PTE) sistemik venöz sistemde oluşan pıhtıların pulmoner vasküler yatağa göçü ile ortaya çıkan klinik tabloya verilen isimdir. Akut derin ven trombozu (DVT) sonrası ortalama %40-60 oranında...
Endoskopi yapılan hastalarda Helicobacter pylori sıklığı ve yerleşim yerinin yaş ve cinsiyete göre dağılımı
Amaç: Çalışmadaki amacımız endoskopi yapılan gastritli hastalarda Helicobacter pylori sıklığı ve yerleşim yerinin yaş ve cinsiyetlere göre dağılımının belirlenmesidir. Yöntemler:Hastanemizde Ocak 2012-Temmuz 2013 tarihl...
Evaluation Of The Peripapillary Retinal Nerve Fiber Layer And Subfoveal Choroidal Thickness In Naive Patients With Diabetes Mellitus With Spectralis OCT
Objective: We aimed to compare the peripapillary retinal nerve fiber layer (pRNFL) and choroidal thickness in naive type 2 diabetic patients without diabetic retinopathy (DR) with healthy subjects. Methods: The study...