Histological and Biochemical Study of Different Doses of Tamoxifen Drug on Liver Of Albino Male Rat
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Tamoxifen is an effective anticancer drug. It's a hormonal treatment against estrogen which is necessary for the growth of cancer cells. This study was conducted to evaluate the negative effects of Tamoxifen on some physiological and histological. Use for this purpose 32 rats of the strain Sprague dawley albino rat and divided into 4 equal groups. 3 groups were given different doses (30, 40, 50)mg/kg body weight of TAM 3 times a week for 8 weeks as well as control group that was injected with physiological solution (normal saline 0.9%). At the end of dosage duration, the blood was collected for the purpose of studying some Biochemical parameters (Liver Functions). The results of Biochemical tests showed significant differences in the treatment groups were the three groups showed a significant increase in the levels of (TSB, GOT, GPT, ALP). Histopathological examination of liver tissues in TAM groups showed histological changes that increased with the increased dose compared to control group such as inflammatory cells infiltration and blood congestion. As well as the occurrence of necrosis in the cells and colleting Neutrophils and Monocytes and Aggregation of mononuclear scatter in the liver parenchyma. The results clearly indicated that Tamoxifen had an adverse effect on liver and blood and chemical parameters that cause hepatotoxicity
Authors and Affiliations
Aqeel H. Qasim, Dr. Abd H. Baraj*
Keywords
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- EP ID EP390408
- DOI 10.9790/3008-1204086776
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