HISTOLOGICAL AND HISTOCHEMICAL CHANGES IN THE LUNG INDUCED BY SHORT AND LONG TERM EXPOSURE TO XYLENE
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 8
Abstract
Inhalation of xylene is a dangerous type of exposure to this chemical. This study was carried out to investigate the effect of xylene on the histoarchitecture of the lung. Twenty five wistars were used for this work. The rats were randomly divided into five groups A, B, C, D and E of five rats each. Group A served as the control and was not to exposed to xylene, while B, C, D, and E was exposed to xylene for 14 days, 28 days, 42 days and 56 days respectively. The animals had difficulty in breathing, wheezed and coughed. The animals were sacrificed after 14 days, 28 days, 42 days and 56 days and the lung harvested and processed using normal histological technique with Papanicolaou staining and Pararosanilin-Toluidine B staining procedures. The result revealed that xylene fume altered the histoarchitecture of lung and esterase and collagen wall. This ranged from mild emphysematous change, inflammation of cells, Collapse of the collagen wall and distortion of esterase. There was significant increase in weight of the animals in all the groups. In conclusion, xylene fume altered the histology and histochemistry of lung tissues and had no effect on body weight of the animals.
Authors and Affiliations
Okoronkwo, Samuel Okafor
Keywords
Related Articles
- EP ID EP626719
- DOI -
- Views 135
- Downloads 0
PHARMACEUTICAL ACTIVITY OF 1,3,4-OXADAIZOLE IN HETEROCYCLIC CHEMISTRY. A REVIEW
Oxadiazole and its derivatives have been focused on for their broadly chemical and biological importance in a previous couple of years. In this review, the Different Synthesis and its biological activities of 1,3,4-Oxadi...
A REVIEW ARTICLE ON DUSHTA VRANA (NON- HEALING ULCER)
Dushta Vrana represent a significant burden to patient, health care professionals, and the health care system. In India, most of the population still reside in poor hygienic and malnourished conditions, hence the inciden...
QUALITY ANALYSIS OF DIFFERENT MARKETED BRANDS OF ATENOLOL (50 MG) TABLETS AVAILABLE IN SYRIA AND COMPARING WITH THE REFERENCE DRUG
There are numerous generics of atenolol tablets available in Syria. The purpose of current study is to assess the physicochemical characters of four brands(A, B, C, D) of atenolol(50mg) tablets advertised in Syria and co...
THE IMPACT OF STRESS ON IMMUNITY, MECHANISM AND PATHWAYS INVOLVED
This is established fact that stress is harmful for human body. There is a need to identify the adaptive and curative measure to manage physiological stress reaction at the time of fight and flight. Usually treatment of...
IDENTIFICATION OF MELANIN
Melanin is a ubiquitous natural pigment that is present in many organs in different species. It is well recognized as a UV absorber and as a protective molecule. It harbors stable intrinsic free radicals and binds metals...