HISTOLOGICAL CHANGES IN KIDNEYS OF ADULT RATS TREATED WITH MONOSODIUM GLUTAMATE: A LIGHT MICROSCOPIC STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Introduction: Monosodium Glutamate (MSG), which is chemically known as AJI-NO-MOTO also familiar as MSG in routine life. MSG is always considered to be a controversial food additive used in the world. It is a natural excitatory neurotransmitter, helps in transmitting the fast synaptic signals in one third of CNS. Liver and kidney play a crucial role in metabolism as well as elimination of MSG from the body. Present study is to detect structural changes in adult rat kidney tissue treated with MSG; observations are done with a light microscope. Materials & Methods: The study was conducted in the department of Anatomy, J.N.M.C, Sawangi (M) Wardha. Thirty (30) adult Wistar rats (2-3 months old) weighing about (200 ± 20g) were used in the current study, animals were divided into three groups (Group – A, B, C). Group A: Control, Group B: 3 mg /gm body weight, Group C: 6 mg /gm body weight, MSG were administered orally daily for 45 days along with the regular diet. Observations & Results: The Mean values of animals weight at the end of experiment (46th day) respectively were 251.2 ± 13, 244.4 ± 19.9 and 320 ± 31.1. Early degenerative changes like, Glomerular shrinkage (GSr), loss of brush border in proximal convoluted tubules and Cloudy degeneration was observed in sections of kidney treated with 3 mg/gm body weight of MSG. Animals treated with 6 mg/gm body weight of MSG showed rare changes like interstitial chronic inflammatory infiltrate with vacuolation in some of the glomeruli, and much glomerular shrinkage invaginated by fatty lobules. Conclusion: The effects of MSG on kidney tissues of adult rats revealed that the revelatory changes are directly proportional to the doses of MSG.
Authors and Affiliations
Singh BR| Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India, Ujwal Gajbe| Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India, Anil Kumar Reddy| Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India, Corresponding author email: kumarlucky48@gmail.com , Vandana Kumbhare| Department of Anatomy, J.N.M.C, Sawangi (Meghe), Wardha, Maharashtra, India
Keywords
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- EP ID EP11335
- DOI 10.5958/2319-5886.2015.00001.6
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