Histological clonal change - A feature for dysplasia diagnosis
Journal Title: Archives of Pathology and Clinical Research - Year 2018, Vol 2, Issue 1
Abstract
Aims: Histological diagnostic criteria are used for the assessment of the degree of dysplasia and hence the risk of cancer progression for premalignant lesions. Clonal changes in the form of hyperorthokeratosis and hyperchromasia that are sharply demarcated from adjacent areas are not currently part of the criterion for dysplasia diagnosis. The objective of this study was to determine whether such clonal change should be regarded as a diagnostic feature for dysplasia. The following histological conditions were used to define such change: (1) hyperorthokeratosis; (2) hyperchromatism but no other features of dysplasia; (3) sharp margin demarcation from adjacent area by both the hyperorthokeratosis and hyperchromasia (clonal change), and (4) no prominent rete ridges, marked acanthosis or heavy inflammation. Lesions fitting these criteria were termed orthokeratotic lesions with no dysplasia.
Authors and Affiliations
Lewei Zhang, Tarinee Lubpairee, Denise M Laronde, Martial Guillaud, Calum E MacAulay, Miriam P Rosin
Keywords
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- EP ID EP560026
- DOI 10.29328/journal.apcr.1001008
- Views 48
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