Histological evaluation of alternative film for regenerative techniques: experimentalstudy in rat mandibles
Journal Title: RSBO - Year 2009, Vol 6, Issue 3
Abstract
Introduction: Today, Teflon is used for many biological applications in medicine and dentistry. In dentistry, it is used especially as a barrier, in the guided tissue regeneration (GTR) and guided bone regeneration (GBR) techniques,presenting different levels of success. Objective: The objective of the present study was to evaluate through histological analysis the use of a Teflon film placed over intra-oral bone defects surgically created in rats. Material and methods: 16 adult male rats (WISTAR) were divided in two groups: group T (test) and C (control). Two experimental monitoring periods were analyzed: one and three weeks. Bone defects were surgically created in the right mandible, with the use of a carbide bur (3 mm diameter), anterior to the mentonian region.In T group, bone defect was covered with a film of Teflon (expanded polytetrafluoroethylene, e-PTFE). In C group, defect was filled only with blood clot. After monitoring periods went through, animals were euthanized. Results: Due to the high malleability Teflon film filled the experimental defects, which caused a local tissue response characterized by the presence of a chronicle and acute inflammatory infiltrate, either at 1 or 3 weeks T groups. In 3-week T group, it was possible to observe the development of bone tissue with initial matrix mineralization only from the edges of the defect. Bone development from the edges also happened in C group, with absence of intense inflammatory processes. However, maintenance of tissue volume was poor. Conclusion: In the present experimental model it was possible to conclude that filling bone defect with Teflon film was prejudicial to local bone repair. To use Teflon film for regenerative techniques it is necessary to improve physical properties, diminishing its malleability.
Authors and Affiliations
Ranulfo AZEVEDO NETO, Saulo LOPES, Ulysses ALMEIDA, João ZIELAK, Tatiana DELIBERADOR, Allan GIOVANINI, Eduardo PIZZATTO
Keywords
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