Histological Spectrum of Adult Onset Nephrotic Syndrome in a Tertiary Care Referral Center
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Introduction: Nephrotic syndrome is one of the most common indication f renal biopsy all over the world. There are very few studies on histopathological spectrum of adult onset nephrotic syndrome in Eastern India. In this present study, we have found increase in incidence of minimal change disease (MCD) in younger adults in Eastern India. Objectives: The aim of the present study is to find out the histopathological spectrum of adult onset nephrotic syndrome in our institute which is the largest tertiary care referral center in Eastern India. Materials and method: After obtaining ethical clearance and written consent from the patient adult patient > 18 years attended in the department of nephrology with proteinuria and fulfilling the criteria for nephrotic syndrome underwent renal biopsy over a period of 18 months. Histopathological finding was correlated with immunofluorescence (IF)finding and clinicopathological correlation done. .Result: Total 47 cases were tested in the study, of which MCD was the most common histologicalpattern and most common on 18-29 years of age group. Other common patterns were IgA nephropathy (IgAN), membranous glomerulonephritis (MGN) and focal segmental glomerulosclerosis (FSGS).Lupus nephritis (LN) was found to be the most common cause of secondaryglomerulonephritis (GN). Conclusion: In present study, MCD was found to be the most common cause in Eastern regionespecially in younger age group. Membranous GN was found to be associated with highest range of proteinuria. Renal biopsy was found to be an essential tool in early diagnosis and interpretation of renal diseases.
Authors and Affiliations
Dr Keya Basu, Dr Suparna De, DrMoumita Sengupta, Dr Subhrojyoti Karmakar, Dr Dipankar Sircar, Prof Dr Arpita Roychowdhury
Keywords
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- EP ID EP434302
- DOI 10.9790/0853-1801076670.
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