Histomorphological study of corneal dystrophies
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction The term Corneal Dystrophy refers to a rare heterogeneous group of genetically determined bilateral symmetric primary diseases restricted to cornea and not associated with previous ocular inflammation The dystrophies are classified based on the layer of cornea involved into superficial stromal and posterior dystrophies each of which is genetically determined Though the clinical features are often characteristic definitive diagnosis is possible only after histological examination The management protocols and visual prognosis vary with the underlying conditions The incidence of the subtypes varies with the geographic locationsObjective To study the prevalence of various subtypes of Corneal Dystrophies in corneal button specimens obtained after penetrating keratoplasty in a referral ophthalmic institute and to correlate with the patients age and sexMaterials and Methods Corneal button specimens received in the ocular pathology laboratory over a period of five years were reviewed Histopathological features of Corneal Dystrophies were studied and subcategorised Cliniopathological analysis was madeResults Out of 660 corneal biopsies reviewed 42 cases were of corneal dystrophy The patients were between 2 and 71 years of age with 14 males and 28 females Macular dystrophy was the most common with 20 cases followed by Congenital Hereditary Endothelial Dystrophy CHED and Fuchs endothelial dystrophy FECD with 7 cases each Epithelial basement membrane dystrophy Reis Buckler Dystrophy RBCD Granular dystrophy were the other typesConclusion Histopathological sub categorisation of various types of Corneal Dystrophies not only helps in understanding the prevalence but also in predicting the genetic link and prognosis of the disease categoryKeywords Cornea CHED Dystrophy Fuch Macular
Authors and Affiliations
Thejaswini MU, Geethamani V, Sushma TA, Suguna BV, Bhargavi Mohan
Keywords
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- EP ID EP473201
- DOI 10.18231/2394-6792.2018.0026
- Views 59
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