Histomorphometric Assessment of the Impact of Bovine Demineralized Bone Graft on Bone Healing Versus Autogenous, Allogeneic and Synthetic Grafts in Experimentally- Induced Critical Size Bone Defects in Rats
Journal Title: Cumhuriyet Dental Journal - Year 2018, Vol 21, Issue 4
Abstract
Aim: Bone tissue has the ability to heal itself (regeneration) and may restore its morphology and function when injured. However, healing may be limited in the case of large wounds. A “critical-size defect” is an intraosseous wound in a particular bone and species of animal that will not heal spontaneously morphologically and functionally during the lifetime of the animal. Autogenous bone grafts have been regarded as “gold standard” for treatment of critical-size bone defects. Known drawbacks of autogenous bone graft have led to research efforts focusing on different graft materials and resulted in several alternative substitutes including xenografts, allografts and synthetic graft materials. The aim of the present study was to perform a histomorphometric study to investigate the effect of bovine demineralized bone graft on bone healing in comparison to autogenous, allogeneic and synthetic graft materials when applied into critical size bone defects with a diameter of 5 mm. Materials and methods: Experimental animals were divided into 4 groups, each having 8 rats. In the control group, a mandibular defect was created and then filled with a bovine graft (Integros Bone Plus XS Adana/Turkey). In the experimental groups, autogenous bone was reinserted into the critical-size defect which was created using a trephine bur in Group I (autogenous group) and Group II received a human graft (Korea Bone Bank (KBB) Gasandong Keumcheongu Seoul/South Korea) to fill the critical-size defect. For Group III, a synthetic bone graft β-tricalcium phosphate (Cerasorb North Carolina/USA) was applied on the critical-size bone defect. Specimens were obtained for histomorphometric examination and rats were sacrificed on day 28. Results: Histomorphometric examination performed on day 28 to evaluate the relative effects of different graft materials on new bone formation showed no significant difference in the volume of newly formed bone between groups receiving autogenous bone graft, allograft and bovine xenograft but a significant difference was observed versus synthetic bone graft group. Conclusion: While autogenous bone graft is currently regarded as the gold standard for bone regeneration, the difficulties in harvesting and application of autografts limit their use. Our results demonstrate that bovine bone graft may be used as a safe and effective alternative to autogenous bone graft.
Authors and Affiliations
Turgay Peyami HOCAOĞLU, Sadık GENÇOĞLAN, Murat ARSLAN, M. Emre BENLİDAYI, Mehmet KÜRKÇÜ
Keywords
Related Articles
- EP ID EP462802
- DOI 10.7126/cumudj.475498
- Views 104
- Downloads 0
Intraoperative Pain During Glide Path Creation with the Use of a Rotary or Reciprocating System
Objectives: The objective of this study was to compare the intraoperative pain levels of patients caused from using different glide path systems in creating the glide path before the root canal shaping the teeth with asy...
The Effect of Desensitizing-Toothpastes on the Bond Strength of Different Restoratives on Coronal/Root Dentin
Aim: The aim of the study was to evaluate the effects of two desensitizing tooth-pastes on the shear bond strength of resin composite and glass ionomer restorative materials to coronal and root dentin. Materials and Me...
Pyogenic granuloma of the incisive papilla: A rare case report
Pyogenic granuloma is a non-neoplastic reactive growth commonly found in the oral cavity and skin. It is benign in origin and may arise due to factors like trauma, local minor irritation and an imbalance in the levels of...
Accuracy of digital panoramic radiographs on the vertical measurements of dental implants
Objectives: Panoramic radiography (PR) is the most commonly used technique to evaluate the dental and associated structures. The aim of this study was to determine the accuracy of panoramic radiographs (PRDs) in planning...
Evaluation of Carabelli’s trait in a group of Turkish patients
Objectives: Dental morphological characteristics are useful for providing information in phylogenic and genetic studies and also for understanding variations within and among species. Carabelli cusp is expressed in sever...