Histopathological Analysis of Liver Lesions in 80 Liver Biopsy Specimens
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 6
Abstract
Background: Liver biopsy serves an important role in the definitive diagnosis of liver diseases, determining the grade and stage of the disease and also in evaluating the effect of therapy. It is particularly useful in the diagnosis of biliary atresia. Material and Methods: 80 percutaneous liver biopsy specimens received in our department over a period of August 2014 to Jan 2018 were studied. Biopsy findings were correlated with biochemical investigations and clinical features. Result: 59 out of 80 cases were neoplasms with 35 metastatic tumors, 22 hepatocellular carcinomas and one case each of non Hodgkin lymphoma and hemangioma. Out of 35 metastatic tumors, 28 were adenocarcinomas along with two cases each of gastrointestinal stromal tumors and squamous cell carcinoma and one case each of malignant melanoma, adenosquamous carcinoma and malignant small round cell tumor. Non neoplastic lesions included seven cases of cirrhosis and four congenital lesions consisting of three cases of biliary atresia and one case of neonatal hepatitis. We had two cases of glycogen storage disease and one case each of fatty change and abscess. Conclusion: The present study showed that hepatic tumors are the most common lesions encountered on liver biopsy. Metastatic tumors especially adenocarcinomas are much more frequent than primary hepatic tumors. Biopsy of the liver is considered gold standard for histopathological characterization of congenital lesions like biliary atresia and storage disorders.
Authors and Affiliations
Dr Yadav Deepika H
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