Histopathological and Immunohistochemical Analysis of Association between Papillary Carcinoma Thyroid and Hashimoto’s Thyroiditis with P63 Immunoprotein
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Neoplastic transformation is a multistep process that results in a continuous spectrum from the physiological state to a fully established neoplasm. Papillary carcinoma thyroid(PTC), the most prevalent of all thyroid carcinomas has been associated with Hashimoto’s thyroiditis(HT). Although the gold standard for the diagnosis of PTC is conventional histology,the other criteria being increasingly used include immunohistochemical staining and molecular profile. The aim of this study is to analyse the histopathological types and to establish the association between Hashimoto thyroiditis and papillary carcinoma by immunohistochemical detection of p63 protein. P63 positivity was found in all cases of papillary carcinoma, occasionally in Hashimoto’s thyroiditis and absent in Hashimoto thyroiditis with papillary carcinoma. The study showed equivocal results regarding the p63 immunoprotein expression in cases of Hashimoto’s thyroiditis with papillary carcinoma. Therefore the association between Hashimoto’s thyroiditis and papillary carcinoma remains ambiguous and molecular analysis is required for further confirmation of their association.
Authors and Affiliations
Geetha Lakshmi. S, Martina. V
Keywords
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- EP ID EP590328
- DOI 10.9790/0853-1601090105
- Views 59
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