Histopathological and x-ray based evaluation of anti-rheumatoid effect of chrysin in freund’s induced arthritis in wistar albino rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 4
Abstract
Background Arthritis is one of the leading cause of disability in the world. A radiographic survey suggested that the prevalence of arthritis rises from 1% below 30 years and 50% in above 60 years. With this background the present study was conducted to evaluate the Anti- rheumatoid effect of chrysin in freund’s induced arthritis in rats. Aim and Objective To evaluate the anti-rheumatoid effect of Chrysin in freund’s induced arthritis in rats. Materials and Methods This study was conducted in the Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University. It was done in the period of Jan 2012-Jan 2013 (1 year). 30 rats were divided in two five groups each group of 6 rats. G-I (Distilled water), G-II (Freund’s complete adjuvant), G-III (Dexamethasone 0.5 mg/kg), G-IV (Chrysin 50mg/kg) and G-V (Chrysin 100 mg/kg). All the animals were treated with their respective drugs for 56 days. –ray of rats joint was taken at 1st ,7th , 14th, 28th and 56th day. At the end of experiment Rats were sacrificed and joint was separated and used for histopathology. Results G-II rats showed significant changes in joint X-ray and histopathology compared to control group. Co- administration of dexamethasone significantly prevented arthritic changes in joint compared to G-II. High dose chrysin showed effect similar to dexamethasone. Conclusion Chrysin administration significantly prevented freund’s adjuvant induced arthritis in rats. It can be used in the treatment of rheumatoid arthritis and other inflammatory joint disorders.
Authors and Affiliations
Vishnu R
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