HISTOPATHOLOGICAL ASSESSMENT OF ORAL SQUAMOUS CELL CARCINOMA OF THE MANDIBULAR REGION
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 60
Abstract
BACKGROUND Oral cancer accounts for 30% of cancers in India.1 Of these, the tumours that abut on mandible show a greater local recurrence. This includes the tumours on mandibular alveolar ridge, lower buccal sulcus, sublingual sulcus and mandibular retromolar area.2,3 So, it is important to assess the histopathological features of these tumours to identify the factors related to prognosis and plan the surgical resection accordingly. The aims of the study- 1. Histopathological characterisation of oral squamous cell carcinoma of the mandibular region. 2. Evaluation of the underlying mandible for marrow invasion and perineural tumour invasion. MATERIALS AND METHODS 50 resection specimens of squamous cell carcinoma of the mandibular region received in Department of Pathology, Medical College, Thiruvananthapuram, and sent from the Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, from May 2000 to August 2001 were included. The clinical factors like site, size of tumour, proximity and fixity to the mandible, history of radiation and evidence of bone invasion were checked. Hemimandibulectomy specimens were cut buccolingually and representative bits were processed after decalcification. RESULTS 72% of the tumours in the lower alveolus showed mandibular bone invasion while those in buccal mucosa and tongue did not. The infiltrative pattern was associated with deeper invasion of the bone. Perineural and intraneural infiltration of inferior alveolar nerve occurred in 16.7% and 5%. Marrow fibrosis was the commonest tissue response to tumour invasion. CONCLUSION Mandibular resection is essential for large tumours, which are located on the alveolar ridge with clinical fixity to the mandible. An infiltrative pattern of bone invasion and perineural involvement are seen in more aggressive tumours.
Authors and Affiliations
Ramdas Das Sheima, Chettithodi Sivasankaran Bindu, Purushotham Rao Latha
Keywords
Related Articles
- EP ID EP228237
- DOI 10.18410/jebmh/2017/727
- Views 109
- Downloads 0
ALCOHOL AS A RISK FACTOR IN HNC, AN ENORMOUS TOLL ON THE LIVES AND COMMUNITIES
INTRODUCTION Head and neck cancer (HNC) is the seventh most common cancer in the world. After smoking, alcohol consumption is a strong associated risk factor for HNC. Alcohol consumption has negative impact on health and...
CAREGIVER BURDEN AMONG PEOPLE CARING FOR PATIENTS WITH SCHIZOPHRENIA
BACKGROUND Caregivers of patients suffering from mental illness report burden in different areas including effects on family functioning, psychological problems, financial problems and health. The aim of the study is to...
OCULAR DISORDERS IN CHILDREN WITH DEVELOPMENTAL DELAY
BACKGROUND In India, an estimated 1.5-2.5% children below 2 years of age are developmentally delayed. A higher incidence of ocular disability is seen in these children, refractive errors and strabismus being most common....
SEMI-QUANTITATIVE PROCALCITONIN KIT FOR EVALUATING SEVERITY AND PREDICTING MORTALITY IN SEPSIS
BACKGROUND Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. Sepsis is caused by an immune response triggered by an infection. Most comm...
RUPTURE OF A PREVIOUSLY SCARRED UTERUS AT 26 WEEKS OF GESTATION
Rupture of the gravid uterus is a catastrophic event to both mother and fetus. Majority of cases occur in women with scarred uteri. This is the case report of a 28 year old lady, G2 P 1 L 1 with 26 weeks of gestation wit...