Abstract

Background: Breast carcinoma is the second common malignancy among women. Pathological prognostic factors in breast cancer are now widely used to predict prognosis of breast carcinoma and to plan its effective management. Aim and Objectives: To analyze the spread and extent of various histological patterns of carcinoma breast, to do grading and staging of the tumors and to correlate above factors with the prognosis. Material and Methods: The present study was a prospective study of histopathological findings of modified radical mastectomy specimens received in the department of pathology of Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik over a period of 2 years and 3 months that is from June 2015 to September 2017. A total of 45 mastectomy specimens were analyzed in this period, using standard histopathology technique. Positive status of Axillary lymph nodes and other prognostic factors were analyzed. Nottingham Prognostic Index (NPI) was used to assess the prognosis. Follow up of all the patients was kept. Results: Out of 45 total cases, the most common histologic type was Invasive Ductal Carcinoma (NOS) (86.67%). The largest tumor size was 14.5cm. Maximum tumors were of Grade II. Out of the 45 cases, 31 (68.88%) cases showed tumor metastasis in axillary lymph nodes. 48.88% of the patients showed poor prognosis category with score greater than 5.4. Conclusion: After keeping follow up with the patients we came to a conclusion that, the lymph node status, tumor size, histologic pattern, histologic grade, necrosis and presence or absence of blood vessel invasion remains the best independent prognostic indicators.

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