Histopathological Evaluation of Meningiomas.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 2
Abstract
Meningiomas are the most frequent primary tumors of the central nervous system (CNS) constituting about 28–30% of primary Central Nervous System Tumours (1,2)They originate from the arachnoidal cap cell, a meningothelial cell in the arachnoidal membrane . Meningiomas account for 15% of all intracranial tumors and usually occur in fourth to sixth decades of life with mean age of 45 years at diagnosis(3)According to site meningiomas are located at parasaggital, convexity, sphenoid ridge, suprasellar, posterior fossa, olfactory groove, middle fossa, tentorial, peritorcular, lateral ventricle, foramen magnum , spinal, orbit or optic nerve sheath, few located at ectopic site. Females have meningiomas more often than males; ratio is 2:1 for intracranial and 4:1 for spinal meningiomas.(4)While they are benign in most instances and may be cured with gross total resection; however, approximately 9-22% of patients experience recurrence and rarely are they frankly malignant leading to metastasis.(5)Known risk factors for recurrence include histological malignancy grade, subtotal resection,young age, specific subtypes, brain infiltration, and high proliferative rate.(6) On gross examination, typical meningioma is lobulated or single, solid mass that is widely attached to the dura mater. On sectioning, meningioma is soft and grayish, sometimes show rubbery consistency due to colonization. Calcification is often present and yellow foci are seen because of the accumulation of lipid within tumor cells. Sometimes grayish black pigmentation is seen because of the colonization of the hyperplastic leptomeningeal melanocytes.(7) Meningiomas (benign) are recognised by their histologic subtype and lack of anaplastic features.Grade II meningiomas (atypical) are defined by one or more of the following four criteria: 1) chordoid or clear cell histologic subtype, 2) four to 19 mitoses per ten high-power field (HPFs), 3) brain infiltration, and 4) three or more of the following five histologic features: small cell change, increased cellularity, prominent nucleoli, sheet-like growth, or necrosis. Grade III meningiomas (anaplastic/malignant) are defined by rhabdoid or papillary subtypes, a histological picture of frank malignancy resembling that of carcinomas, melanomas, or high grade sarcomas, or 20 or more mitosis per ten HPFs.(8) The aim of the study was to investigate a large number of human meningiomas, consecutively operated during a five-year period, in order to record the frequency of various subtypes and malignancy grades according to the latest WHO classification (2016) (6)
Authors and Affiliations
Priya Vijaykumar Gameti
Keywords
Related Articles
- EP ID EP537889
- DOI -
- Views 97
- Downloads 0
Polymerase Chain Reaction and Its Applications in Dentistry
A variety of molecular biology methods have become obtainable in the previous years and one of the most innovative of these techniques regarding nucleic acid analysis is the polymerase chain reaction (PCR), which was fir...
Heredo-Familial Transmission of Allergies In India - Son Inherits The Disease From The Father And Daughter From The Mother
Background: Allergies are known to be heredofamilial diseases. Which parent confers an allergy risk factor to the child is an unanswered question in India. Methods: 1353 consecutive patients suffering from one or more...
A Case Report on Gitelman Syndrome: Rare Cause of Hypokalemia
Gitelman syndrome is an autosomal recessive renal tubular disorder characterized by hypokalemic metabolic alkalosis which is a common clinical problem for practicing endocrinologists and nephrologists. A 30 year old fema...
Sustained Release of Calcium Ions &Ph Maintenance from Different Vehicles containing calcium hydroxide- an in vitro study
AIM: The aim of the in vitro study is to determine the Sustained Release of Calcium Ions & pH maintenance from different vehicles containing calcium hydroxide using ultraviolet spectrophotometer and pH meter. Material An...
A Study to Compare between Invasive Blood Pressure and Noninvasive Blood Pressure Measurement among Critically III Children In A Tertiary Care Hospital In Kolkata
Objective: To compare invasive arterial blood pressure with non-invasive arterial bloodpressure in critically ill children. If NIBP can be used interchangeably with IBP to monitor very sick kids Design: Cross sectional,...