HISTOPATHOLOGICAL PATTERNS OF LIVER DISEASES IN MEDICAL AUTOPSIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 31
Abstract
BACKGROUND Liver is the site for wide spectrum of diseases, primary as well secondary, which maybe symptomatic or silent and incidentally diagnosed during routine investigation or autopsy examination. The main purpose of our study was to identify different spectrum of histopathological findings of liver in medical autopsies. MATERIALS AND METHODS The study was conducted in the Department of Pathology, Regional Institute of Medical Sciences (RIMS), Imphal. All the consecutive liver specimens dissected out during medical autopsy and postmortem were included in the study. Detailed clinical information including age and sex were obtained. All the liver specimens were examined meticulously and the gross findings were noted down. Histopathological slides were prepared from the representative areas and findings recorded. RESULTS In the present study, a total of 330 liver specimens were examined from medical autopsies during the period of 5 years. Among them, 39 cases were autolysed and remaining 291 cases were analysed grossly and histologically. 249 (85.5%) cases were males and 42 (14.4%) cases were females. 71 (24.39%) cases had no obvious pathology, followed by fatty liver (20.96%), portal triaditis (18.55%), cirrhosis (14.08%), hepatitis (11.34%) and steatohepatitis (5.15%). Other important cases like liver necrosis (2.40%), granulomatous lesion (0.68%), tuberculosis (0.68%), chronic venous congestion (0.68%), malaria pigment (0.34%), leukaemic infiltration (0.34%) and bile duct hamartoma (0.34%). Fatty liver and cirrhosis was found to be most common in the age group of 41-50 years with male predominance. Incidentally, diagnosed liver diseases are not uncommon in medical autopsy. CONCLUSION We concluded that the autopsy examination of liver is very helpful to identify silent liver diseases as it is very common in apparently healthy individuals.This data may be utilised for a medical audit.
Authors and Affiliations
Sampa Choudhury, Rajesh Singh Laishram, Seter Potom
Keywords
Related Articles
- EP ID EP217957
- DOI 10.18410/jebmh/2017/354
- Views 91
- Downloads 0
SEXUAL DYSFUNCTION INDUCED BY ANTI-PSYCHOTICS AND ANTI-DEPRESSANTS IN DRUG NAIVE PATIENTS – A COMPARATIVE STUDY
BACKGROUND The aim of this study was to determine and compare sexual dysfunction caused by anti-psychotics and anti-depressants in drug naïve patients. MATERIALS AND METHODS Patients diagnosed as drug naïve schizophrenic...
VARIABLE PRESENTATIONS OF ACUTE APPENDICITIS
BACKGROUND Acute appendicitis is the commonest cause of pain in all age groups, which if not diagnosed and treated can lead to perforation and peritonitis. So early diagnosis and prompt treatment can reduce morbidity and...
A CLINICO-INVESTIGATIVE STUDY OF ALOPECIA AREATA WITH SPECIAL REFERENCE TO ITS ASSOCIATION WITH VARIOUS SYSTEMIC AND DERMATOLOGICAL DISORDERS
BACKGROUND Alopecia areata is an immunologically mediated disorder characterized by focal to diffuse hair loss. AA is hypothesized to be an organ specific autoimmune disease mediated by T lymphocytes directed against the...
STUDY OF HEPATOPROTECTIVE ACTIVITY OF EMBLICA OFFICINALIS (AMLA) IN ALBINO RATS
BACKGROUND The study has been undertaken to evaluate the hepatoprotective activity of fruits extract of Emblica officinalis on carbon tetrachloride-induced hepatotoxicity on Albino rats. MATERIALS AND METHODS The present...
A RETROSPECTIVE STUDY OF BLOOD GROUPS IN HEAD AND NECK MALIGNANCIES
BACKGROUND Malignancy is a unique disease with abnormal proliferation of cells with the properties of invasion, anaplasia and metastasis. It accounts for around 12% of the deaths throughout the world. Blood does vital ta...