Histopathological Results of Endothelıal Injury in Great Saphaneous Vein Harvested For Coronay Artery Bypass Surgery
Journal Title: Hippocrates Medical Journal - Year 2021, Vol 1, Issue 1
Abstract
Abstract Aim The most important determinant of the success of coronary bypass surgery is the long- term remaining open of primary autograft conduit, vena saphaneus magna. Endothelial injury is to be accepted as leading reason of greft occlusion. In this study, we aimed to displace histopatholojical consequences of endothelial injury occured on great saphenous vein. Material and Methods Between May 2011 and June 2011, 10 patients who underwent coronary artery bypass surgery were included to the study. Great saphenous vein samples were taken before and after harvesting the vessel. Samples were investigated histopathologycally, immunohistochemically and via tunel studies to displace endothelial injury. Results Endothelial cell shapes were broken in harvested vessels. Thickness of subendothelial layer and number of stoplasmic vacouls and collagenous fibers in subendothelial layer was increased. Also, endothelial cell eNOS positivity, CD-34 positivity and TUNEL positive endothelial cell number were much more higher in harvested vessels. Conclusion In order to minimalize the endothelial injury in great saphaneous vein during coronary artery bypass surgery; different harvesting, preserving and usage ways are to be compared with each other with prospective studies
Authors and Affiliations
Muhammet Murat CANTÜRK, Hayrettin TEKÜMİT
Keywords
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- EP ID EP698837
- DOI 10.29228/HMJ.4
- Views 82
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