Histopathological signs and their relationships with survival in chronic allograft nephropathy
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2016, Vol 8, Issue 10
Abstract
Aim: To investigate possible factors contributing to chronic allograft dysfunction (CAD), efficacy of histopathological evaluation in recipients with chronic allograft nephropathy (CAN), and determinative role of histopathological signs in graft survival. Methods: Data of the recipients who underwent renal transplantation (n=270) 10 years in our department were evaluated. The recipients were evaluated in 3 groups as normal allograft function (NAF) group (n=154) and CAD (n=64) and CAN (n=52) groups. Results: Regarding the allograft survival, the NAF group had the best allograft survival. The frequency of hepatitis C virus (HCV) positivity was significantly lower in the NAF group. Although not significant, the frequency of HCV differed between the CAN patients with and without glomerulopathy (34% and 23.5%, respectively). According to the 3-year allograft survival, graft loss was observed to be earlier in the patients with transplant glomerulopathy, without a significant difference. The frequency of proteinuria was higher in the CAD and CAN groups than in the NAF group and proteinuria was appeared firstly in the CAN group and then in the CAD and NAF groups. Fibrointimal thickening was present in 17 patients in the CAN group and the graft survival was observed to decrease with an increase in the fibrointimal thickening. In the CAD group, 30 patients had mild fibrosis and 20 had moderate/severe fibrosis. Tubulointerstitial fibrosis was more severe in the patients who received cyclosporine A. Conclusions: CAN after renal transplantation is frequently encountered and the risk of developing CAN increases in the long term after transplantation.
Authors and Affiliations
Ali Abbas Ozdemir and Murat Altay
Keywords
Related Articles
- EP ID EP405144
- DOI -
- Views 136
- Downloads 0
Isolation identification and characterization of feather degradable bacteria in Thanjavur (Dt)
Feather waste are generated in large quantities as a byproduct of commercial poultry processing as well as through natural process. Feathers are made up of primarily keratin which is resistant to common proteolytic enz...
Prolonged hypotension and postural headache after spinal anesthesia, intracranial hypotension similar clinical picture
We aimed to present a 24 years old male patient that had similarities with intracranial hypotension accompanied headache, syncope attacks, persistent and prolonged hypotension (both ortostatic and supine position) after...
Selection of transjugular intrahepatic portosystemic shunt stents for controlling portal hypertension
Background: Nowadays, transjugular intrahepatic portosystemic shunt (TIPS) has become a mainstay treatment option for the management of portal hypertension-related complications in liver cirrhosis. Accumulated evidence h...
A comparitive study of three doses of intramuscular iron versus hundred tablets of oral iron for propylaxis of anemia in pregnant women
Anemia is responsible for 40 to 60% of maternal death in non industrialized countries. The women are well aware about the tetanus toxoid , this can be used as an opportunity to give intramuscular iron to the patients for...
Knowledge, attitude, and practice of voluntary blood donation among medical students of pdu medical college rajkot
Background: In spite of extensive promising research, a true substitute for blood and blood components may not be available for many years (1).Therefore; blood donation by humans will continue to be the major source for...