Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
Journal Title: Journal of Interdisciplinary Histopathology - Year 2012, Vol 1, Issue 1
Abstract
In must of the developing countries especially in Africa antimalaria drugs are taken regularly either to treat or prevent malaria. The rats were randomly divided into 3 groups of 5 each and tested as follows: - Group O- control (water), Group A – 2mg/kg and Group B - 6mg/kg. The animals were sacrificed after the 7th day. There was no mortality caused by the drug but dizziness in the animals. In the group administered with 2mg/kg of oral artesunate where was no form of distortion in the tissue architecture of the liver, but in the group administered with 6mg/kg of artesunate, artesunate caused sinusoidal congestion, infiltration of inflammatory cells and there was loss of tissue architecture. Drugs are produce to combat illnesses but may turn out be harmful when administered wrongly. In must of the developing countries especially in Africa antimalaria drugs are taken regularly either to treat or prevent malaria. They are taken such that one could even imaging if it is a food supplement
Authors and Affiliations
Felix Onyije, Josiah Hart
Keywords
Related Articles
- EP ID EP103730
- DOI 10.5455/jihp.20120606081137
- Views 118
- Downloads 0
Characterization of the blood–brain barrier in pediatric central nervous system neoplasms
Objective: The normal blood–brain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship oc...
P53 immunohistochemical staining patterns in benign, premalignant and malignant lesions of the oral cavity: A study of 68 cases
Objectives: The p53 tumor suppressor gene is a frequent target for mutations in a variety of tumors. The mutated gene is more stable than the normal gene and can be detected by immunohistochemical methods. The aim of the...
Imerslund-Gräsbeck Syndrome: The Significance of the Annular Deposits or Structures Determined by Electron Microscopy
Objectives: Imerslund-Gräsbeck syndrome (IGS) with or without proteinuria is a rare autosomal recessive disorder seen in childhood and it is commonly resulting in megaloblastic anemia due to cobalamine deficiency. There...
Anabolic Androgen-induced Intrahepatic Cholestasis Presented With Normal γ-Glutamyl-Transpeptidase
The indisputable hepatotoxicity of anabolic androgen steroids has already been well substantiated in the literature, eventhough the exact pathophysiologic mechanisms are still being elucidated. Androgen-induced liver inj...
On the use of human tissues in research and practice