HIV screening strategies in blood donors: a cost-effectiveness analysis
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 1
Abstract
Objective To analyze the cost and effectiveness of different HIV screening strategies based on multi-center HIV residual risk study, so as to provide reference for blood centers to adopt appropriate HIV testing strategies. Methods According to the HIV screening and confirmation of blood donors in three blood centers in Anhui Province, the residual risk of different HIV screening strategies was estimated. A decision tree model was established to analyze the cost-effectiveness differences of three different screening strategies under current domestic policies. Results The residual risk of anti-HIV-1 +2 ELISA, HIV Ag/Ab1+2 ELISA and ELISA+NAT were 1.17×10-6,0.84×10-6 and 0.59×10-6, respectively. According to decision tree model analysis, HIV Ag/Ab1+2 ELISA had a cost-effectiveness advantage over anti-HIV 1+2 ELISA when there was no NAT, but the advantage of HIV Ag/Ab1+2 ELISA disappeared when there was one NAT. The cost of HIV reagents, the cost of HIV treatment and the cost of false positive discarding were sensitive factors of the model. Conclusion In this area, one anti-HIV 1+2 ELISA combined with one NAT has a cost-effectiveness advantage. Blood centers need to confirm and evaluate the ELISA reagents used before conducting HIV screening. Under the premise of ensuring sensitivity, reagent cost and reagent false positive rate are the key factors.
Authors and Affiliations
Hui HUANG, Tao ZHOU, Zheng ZHU, Yi MA, Li CHEN, Wanping DUAN, Ling LI
Keywords
Related Articles
- EP ID EP738740
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.01.007
- Views 45
- Downloads 0
Analysis of HLA allele-specific antibodies and Eplets in patients with platelet transfusion refractoriness
Objective To analyze the specificity and Eplets of HLA allele-specific antibody in patients with platelet transfusion refractoriness (PTR). Methods HLA-A and B genotypes were detected by PCR-SBT, and HLA-Ⅰ antibodies in...
Analysis of confidential unit exclusion status of voluntary blood donors in Hefei
Objective To explore the status of confidential unit exclusion(CUE) status among voluntary blood donors in Hefei, so as to provide scientific basis for blood safety. Methods From 2012 to 2021, 57 out of the 1 158 272 vol...
HCV evolution and positive selection sites of HCV NS5B region among intravenous drug users in Guangdong
Objective To learn the situation of the evolution process of HCV virus population and the selection pressure of HCV NS5B in intravenous drug users (IDUs) in Guangdong. Methods 141 blood samples from hepatitis C virus (HC...
Application of blood/fluid warmer during plateletpheresis in winter and its nursing
Objective To study the safety, effectiveness and nursing of blood/fluid warmer during the process of plateletpheresis in winter. Methods The blood re-transfusion speed during plateletpheresis in winter and the time of bl...
Serological and molecular biological analysis of Aw43 subtype: report of two cases
Objective To conduct serological identification and molecular study of two patients with ABO ambiguous blood group. Methods The serological tests were conducted by the tube method. DNA direct sequencing was performed to...