HIV screening strategies in blood donors: a cost-effectiveness analysis
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 1
Abstract
Objective To analyze the cost and effectiveness of different HIV screening strategies based on multi-center HIV residual risk study, so as to provide reference for blood centers to adopt appropriate HIV testing strategies. Methods According to the HIV screening and confirmation of blood donors in three blood centers in Anhui Province, the residual risk of different HIV screening strategies was estimated. A decision tree model was established to analyze the cost-effectiveness differences of three different screening strategies under current domestic policies. Results The residual risk of anti-HIV-1 +2 ELISA, HIV Ag/Ab1+2 ELISA and ELISA+NAT were 1.17×10-6,0.84×10-6 and 0.59×10-6, respectively. According to decision tree model analysis, HIV Ag/Ab1+2 ELISA had a cost-effectiveness advantage over anti-HIV 1+2 ELISA when there was no NAT, but the advantage of HIV Ag/Ab1+2 ELISA disappeared when there was one NAT. The cost of HIV reagents, the cost of HIV treatment and the cost of false positive discarding were sensitive factors of the model. Conclusion In this area, one anti-HIV 1+2 ELISA combined with one NAT has a cost-effectiveness advantage. Blood centers need to confirm and evaluate the ELISA reagents used before conducting HIV screening. Under the premise of ensuring sensitivity, reagent cost and reagent false positive rate are the key factors.
Authors and Affiliations
Hui HUANG, Tao ZHOU, Zheng ZHU, Yi MA, Li CHEN, Wanping DUAN, Ling LI
Keywords
Related Articles
- EP ID EP738740
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.01.007
- Views 51
- Downloads 0
Health economics evaluation of the cost and effectiveness of gray zone setting in blood ELISA screening
Objective To analyze the cost-effectiveness of ELISA grey area strategy through establishing the health economics model. Methods The serological grey area strategy evaluation model was composed of screening strategy subd...
Establishment of an resilience evaluation index framework for blood service system under emergency support
Objective To construct an index framework for the evaluation of blood service system resilience under emergency support, and improve the ability of blood centers to deal with emergencies. Methods The contents of evaluati...
Potential value of differential expression of CDC42 gene in adult and umbilical cord blood reticulocytes
Objective To explore critical regulatory genes in the hemoglobin switch process by analyzing transcriptomic data from the GSE6236, GSE17639 and GSE35102 datasets. Methods The mRNA expression profiles of the three dataset...
Establishment of a method for detecting the potency of recombinant human coagulation factor Ⅶa for injection
[Objective] To establish a method for detecting the potency of recombinant human coagulation factor Ⅶa for injection. [Methods] By adding the sample and factor Ⅶ deficient plasma to the sample cup and activating the reac...
Establishment of human monoclonal hybridoma cell lines specific for PP1Pk antigens from peripheral B lymphocytes of a p[Tj(a-)] donor
Objective To establish lymphoblastoid cell line (LCL) and human monoclonal antibody cell lines against PP1Pk antigens from a donor with rare p[Tj(a-)] phenotype. Methods Peripheral blood mononuclear cells (PBMCs)of an O...