HLA A24 Associated Tumor Immunity in HER2/neu Positive Breast Cancer
Journal Title: RECENT ADVANCES IN PATHOLOGY AND LABORATORY MEDICINE - Year 2017, Vol 3, Issue 2
Abstract
Breast carcinoma is the most common tumor in women and it has resulted in significant morbidity and mortality. Recognition of tumor-associated antigens (TAA) by HLA class I-restricted CD8+ T cells is fundamental for the detection and destruction of malignant cells. HLA A24 has been shown to be associated with presenting peptides in breast carcinoma, which can be targeted for cancer immunotherapy. Overexpression of the HER2 receptor tyrosine kinase is associated with more advanced-stage disease at presentation and a rapidly progressive clinical course. Here we present a case of a 57-year-old female, who presented with a left breast lump. On histopathological examination, diagnosis of infiltrating ductal carcinoma was made . The patient had ER, PR negative and HER/neu positive cancer with nodal metastasis to supraclavicular lymph nodes. Course of Antracycline-based chemotherapy was started. Patient showed no signs of recurrence till the time of writing the article
Authors and Affiliations
Dr. Ravi Pratap Singh
Keywords
Related Articles
- EP ID EP215564
- DOI 10.24321/2454.8642.201702
- Views 97
- Downloads 0
Entamoeba Histolytica Infesting Colonic Malignancy: First Series of Four Cases
Entamoeba histolytica infections of the gastrointestinal tract are common in the developing world. Only two isolated cases of colonic amoebiasis with colon carcinoma have been described in literature. Here, we describe u...
Pathological Assessment of Response to Neoadjuvant Chemotherapy among Carcinoma Breast Patients in a Tertiary Level Hospital
Background: The role of the pathologist reporting a case of post-chemotherapy carcinoma breast involves not just looking for residual carcinoma, but also classifying the patient into a response category, based on histolo...
Squash Smear Technique in Rapid Intraoperative Diagnosis of Brain Tumors
The role of rapid intraoperative diagnosis is crucial to neurosurgeons to not only define surgical approach, but also to ensure that minimum injury is caused to normal structures surrounding the lesion. Intraoperative cy...
Clinicopathological Spectrum of Pancytopenia in Tertiary Care Centre in Northern India
Introduction: The term pancytopenia refers to a reduction in all three formed elements of blood-erythrocytes, leucocytes and platelets. It is not a disease entity, but rather a triad of findings that may result from a nu...
Diagnostic Accuracy of USG-Guided FNAC in Gall Bladder Mass
Introduction: Malignancy of gall bladder is quite common. However, it cannot always be diagnosed only by clinical history and examination. We have evaluated diagnostic accuracy of USG-guided FNAC in GB mass.