HLA-DR Frequency in Individuals with Rheumatoid Arthritis and Lung Affection
Journal Title: Journal of Rheumatic Diseases and Treatment - Year 2016, Vol 2, Issue 2
Abstract
Objective: Establishing the frequency of HLA-DR antigens in a group of individuals with rheumatoid arthritis (RA) and investigate the correlation of such antigens with pulmonary involvement. Participants and methods: The sample comprised 97 individuals. HLA-DR was genotyped by means of polymerase chain reaction amplification. Results: A total of 54 participants (56.0%) exhibited extra-articular manifestations, most frequently subcutaneous nodules (19.0%). Lung assessment detected affection in 54 (55.7%) participants. HLA-DRB4*0101 was the most frequently found allele, followed by HLA-DRB1*0401, HLA-DRB3 and HLA-DRB1*0101, whereas the most frequent alleles were HLA-DRB1*0901, HLA-DRB4 and HLA-DRB1*1201 in the participants with lung affection. Conclusion: HLA-DRB4*0101 was the allele most frequently found overall, and HLA-DRB1*0901 was the most frequent allele among the participants with lung affection; however, the association was not statistically significant.
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