Homocysteine and Atherogenic lipid profile as Markers of Atherotherombatic Disease among Sudanese Patients with Diabetes Mellitus
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 9
Abstract
Abstract:Atherosclerosis is associated with increased inflammatory activity and risk of vascular disease.However, the factors that promote inflammation are not apparently clear. The aim of the present study was to detect homocysteine (Hcy) in urine as a marker for a therothombatic disease among Sudanese patients with Type2 diabetes mellitus with other markers as predictors of cardiovascular disease. A case control study , was conducted included a total of 100 individuals (60 patients and 40 apparently healthy) age was matched in both groups (ranged from 35 to 75 years) 65% male and 35% female, atherogenic lipid profile and HbA1c were measured by Biosystem 350 and Hcy was detected qualitativly by using Spaeth and Barber Modification method Silver – Nitroprusside test. Data analysis was done by using SPSS version 21 and the results revealed that 25 % of the patients had Hcy positive (+ve) while 35 % had Hcy negative (-ve). There was a significant increase of level of total cholesterol, LDLc, HbA1c and significant decreased level of HDLc between study groups. No statistical deffirance was found in levels across gender of patients. The results showed a positive correlation between total cholesterol, LDLc, HDLc and duration while a negative correlation was found with duration and HDLc. Positive correlation was found between BMI and HbA1c, total cholesterol, LDLc, HDLc. In conclusion, Homocysteine is related to CVD risk mildly elevated of homocysteine being an independent risk factor for atherothrombatic disease among Type2 Diabetes Mellitus. Keywords:Homocystine, Cardiovascular disease, Atherogenic lipid, HbA1c, BMI
Authors and Affiliations
AbdelA zizHamza, Mariam Abbas Ibrahim
Keywords
Related Articles
- EP ID EP371393
- DOI -
- Views 62
- Downloads 0
Knowledge and awareness of the medical students regarding the scope of the forensic pathology
Abstract: The field of forensic includes many types of workers. The forensic pathologists are the medical doctors that are involved in the autopsies and other kind of investigations. But many of the medical students are...
Cardiotoxicity of Trastuzumab in Adjuvant Situation: A Prospective Study of 100 Cases
Abstract:Breast cancer is the most common cancer of women in the world. Its mortality has decreased considerably due to the progression of cancer treatments. Trastuzumab is advancement in oncology but its cardiac toxicit...
Effect of Pleural Effusion and Thoracentesis on PFT
Pleural effusion is a very common cause of dyspnoea in many patients due to chest pain and restricted respiratory mechanics. Irrespective of underlying etiology, patients get significant relief after therapeutic thoracen...
A Histomorphological Study of Intestine Resections at a Rural Tertiary Care Centre
Technological advancement like chromoendoscopy, autofluorescence and magnification endoscopy has propelled usage of endoscopy for pre-operative diagnosis. Intestine resection now accounts for less than 1% of all surgerie...
Non-Traumatic Spontaneous Rupture of Aortic Aneurysm with Dissection of Aorta
Abstract: Aortic dissection is very serious and emergency condition where death immediately follows the tear in wall aorta. As the tear extends, blood can flow in between the wall of blood vessel called as dissection of...