Homocysteine and Lipid Profile in Patients with Coronary Artery Disease
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 9
Abstract
Aim of the study: To find out whether there is any significant correlation between concentrations of homocysteine level, hypercholesterolemia, diabetes mellitus, smoking and hypertension in coronary artery disease. Background: Cardiovascular diseases are the major cause of morbidity and mortality worldwide. Diabetes mellitus, obesity, hypercholesterolemia, smoking and hypertension have been recognized as major risk factors for cardiovascular diseases. A new class of emerging risk factor is elevated plasma homocysteine level. This study aims to determine whether there is any significant association between homocysteine lipid profile and other parameters in acute coronary artery disease. Objectives: 1. To determine the relation between homocysteine and coronary artery disease. 2. To study the lipid profile and other parameters in patients with coronary artery disease in our population. Settings and Design: Case control study in a tertiary care hospital, Kozhikode, Kerala. Materials and Methods: Patients in the age group of 20 to 60 years with first attack of acute coronary artery disease of both sexes are included in this study. Sample size was 30 cases and 60 controls. Study period was one year. Levels of homocysteine, fasting lipid profile and other parameters are assessed. Results: The levels of serum homocysteine, total cholesterol, LDL and fasting blood sugar showed significant increase in cases than in the controls. Triglycerides and HDL levels did not show any associated increase in patients with CAD. Conclusion: The study reveals homocysteine, diabetes mellitus, hyperlipidemia, hypertension, obesity and smoking has definite role in the generation of coronary artery disease in the patients belonging to the District of Kozhikode.
Authors and Affiliations
Jayarajan Karumarakkal
Keywords
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