Homocysteine, antioxidant vitamins and lipids as biomarkers of neurodegeneration in Alzheimer’s disease versus non-Alzheimer’s dementia
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2016, Vol 23, Issue 1
Abstract
[b]Introduction and objective.[/b] Evidence for the benefit of antioxidants’ based therapeutic intervention in dementia are inconsistent. Parallel studies in disease forms of dementia different than Alzheimer’s are even less conclusive. In this study, the role of serum levels of homocysteine (tHcy), lipids and antioxidants in predicting the risk of cognitive decline in Alzheimer’s disease (AD) versus non-Alzheimer’s dementias (n-AD). The objective was to add to the ongoing cumulative research to establish the biochemical baseline for potential nutri-therapeutic intervention in different forms of dementia. [b]Materials and method:[/b] 65 participants with dementia (DP-s) were divided into two groups: ADP – patients with Alzheimer’s disease and n-ADP – patients with dementia of a different etiology than primary neurodegenerative dementia in the course of Alzheimer’s disease. Cognitive function was assessed by Mini-Mental State Examination (MMSE) and related to plasma levels of tHcy, folate, vitamins B-6, B-12, lipids and vitamins A and E for both groups. Also examined were associations between cognitive impairment and several variables (age, education, duration of dementia) that might confound nutrition-cognition associations. [b]Results.[/b] A significant reduction in serum vitamin A levels and elevation of total cholesterol levels were shown for the DP-s group compared to those in the control group. Moreover, significant differences were found in MMSE data and serum vitamin E and tHcy levels between patients with ADP and n-ADP. The scores for MMSE showed a correlation with the vitamin E levels and duration of dementia in the ADP group and/or correlation with tHcy, levels of vitamins A and/or E, and duration of dementia in the n-ADP group. [b]Conclusions.[/b] The results obtained suggest that elevated serum tHcy and decreased levels of vitamins A and E are associated with an increased risk of non-Alzheimer’s dementias, although further studies involving a larger cohort are now needed to verify these results.
Authors and Affiliations
Grzegorz Raszewski, Roman Chwedorowicz, Agnieszka Chwedorowicz, Katarzyna Gustaw Rothenberg
Keywords
Related Articles
- EP ID EP79339
- DOI 10.5604/12321966.1196878
- Views 135
- Downloads 0
Anti-tobacco education: the need for trials of greater length and rigor
Dear Editor,Kanicka et al. are to be praised for their excellent report into the effects of an anti-tobacco education programme. [1] The programme improved knowledge but seemed to have no effect on the hard outcome of be...
Emotional attitudes of young people completing secondary schools towards genetic modification of organisms (GMO) and genetically modified foods (GMF)
Objective. The objective of the study was recognition of the opinions of adolescents completing secondary schools concerning genetically modified organisms and genetically modified food, especially the respondents’ emoti...
Design management of functional foods for quality of life improvement
The paper examines the benefit of bread enriched with antioxidants on oxidative stress, and on the quantities of hydrosoluble antioxidants in a group of human subjects. The home–management of functional foods strategy se...
Post-exposure anti-rabies prophylaxis in humans exposed to animals in Lublin province (Eastern Poland) in 2006-2011
The aim of our study was to analyze medical records from years 2006-2011 of all patients exposed to animals and consulted at the Dispensary of Rabies Prophylaxis in the Department of Infectious Diseases at the Medical Un...
Emotional changes occurring in women in pregnancy, parturition and lying-in period according to factors exerting an effect on a woman during the peripartum period
[b]Introduction[/b]. Pregnancy, parturition and childcare, which are important moments in a woman’s life, are connected with many emotional states of a future mother, a pregnant woman and a lying-in woman. The perinatal...