Homocysteine, folate and vitamin b12 status in patients with coronary artery disease in young age
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Rising incidence of coronary artery disease in India which is rather common causes of morbidity and mortality is not good news. Even by conservative estimate Indian spending an amount that’s nearly 40% entire central Government health budget for the treatment of CAD. Hyperhomocysteinemia is considered as an independent risk factor of premature Coronary Artery Disease (CAD), but the probable role of homocysteine along with biochemically related folate & vitamin B12 with homocysteine in early onset of CAD is not well studied in this part of country. The aim of this study was to assess the role of hyperhomocysteinemia, folate and vitamin B12 deficiency in the development of premature CAD. Materials and Methods: We have performed observational case-control study in total 200 participants having age more than 20 years in both male and female sex, out of these 100 are patients suffering from CAD who were admitted for selective coronary angiography in academic tertiary care hospital in Ahmedabad and 100 healthy controls group participants attended the said institute. The homocysteine, folate and vitamin B12 concentration were measured using standard reagent kit on Abbott AxSYM close system. Result: Mean homocysteine in study group was significantly higher in study group compare to control group (33.02+/-17.41 μmol/l; 13.88+/-3.86 μmol/l). Mean homocysteine level in each age group of study group patient is significantly high than the control group participant (P < 0.001). Mean folate and vitamin B12 level is lower in each age group of study group patients than control group participants. Mean serum folate (7.13+/-3.46 ng/ml versus 12.35+/-3.36 ng/ml) and vitamin B12 (156.41+/-127.36 pg/ml versus 449.86+/-169.90 pg/ml) level are lower in study group than the control group participants respectively. Folate and vitamin B12 shows negative correlation with homocysteine. There was a significant positive correlation between homocysteine and age is observed while folate and vitamin B12 shows negative correlation with age. Conclusion: We may conclude from our study that increase homocysteine level may be one of the risk factor of CAD in young age. Our study also shows that age is non-modifiable while folate and vitamin B12 deficiency are modifiable risk factor of hyperhomocysteinemia.
Authors and Affiliations
Patel J. D. , Chakrabarti C.
Keywords
Related Articles
- EP ID EP296055
- DOI 10.18231/2394-6377.2017.0031
- Views 79
- Downloads 0
A study of association of sex hormone milieu with lipid profile for assessment of cardiovascular risk in adult women
Introduction: Women continue to have a high cardiovascular mortality than men in the past 20 years which is underestimated. Cardiovascular disease is clearly polyfactorial, and data on endogenous hormones may improve our...
Homocysteine, folate and vitamin b12 status in patients with coronary artery disease in young age
Introduction: Rising incidence of coronary artery disease in India which is rather common causes of morbidity and mortality is not good news. Even by conservative estimate Indian spending an amount that’s nearly 40% enti...
Association of serum amylase with insufficient insulin action in Type I and Type II Diabetes Mellitus and Metabolic syndrome
Background: Metabolic syndrome (MetS) and Diabetes mellitus (type I and type II) are emerging as epidemics among non communicable diseases. A lot of research has been done on hyperglycemia in Diabetes mellitus and Metabo...
Prevalence of Haemoglobinopathies in Punjabi population
Background: The prevalence of thalassemias and various hemoglobinopathies are a major public health problem in Punjabi population. These cases are mainly overlooked and thus only treated as a part of anaemia. Thus it is...
Study of free radicals (malondialdehyde) in pre-eclampsia and eclampsia in correlation with uric acid and total proteins
Introduction Oxidative stress is a normal phenomenon in normotensive pregnancy however in preeclampsia oxidative stress is exaggerated may result in a greater potential for endothelial oxidative damage It has been report...