HORMONAL ASSESSMENT IN ACNE VULGARIS IN WOMEN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 94
Abstract
BACKGROUND Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit characterised clinically by nonâinflammatory lesions, open and closed comedones and papules or pustules and nodules of varying degree of inflammation and depth, distributed predominantly over face, back and chest. There are various aetiopathogenetic mechanisms and the major pathogenic factors involved are hyperkeratinisation, obstruction of sebaceous follicle resulting from abnormal keratinisation of the infundibular epithelium, stimulation of sebaceous gland secretion by androgens and various hormones and microbial colonisation of pilosebaceous units by P. acnes which promotes perifollicular inflammation. Of note, hormonal therapies are indicated in severe, resistant-to-treatment cases and in those with monthly flare-ups and when standard therapeutic options are inappropriate. So based on grading of acne and duration of lesions and time of presentation, hormonal assessment plays an important role in the management of acne vulgaris. MATERIALS AND METHODS Hormonal evaluation is not mandatory for those who experience short bouts of onset and offset or those who respond well to standard treatments. However, in the more resistant cases and for those who fail to respond to conventional therapies and based on the grading endocrinal evaluation along with investigations- lipid profile, thyroid profile and ultrasound abdomen are important tools in the management of acne vulgaris. However, in our study, 25 female patients aged between 16 - 35 years who failed to respond to novel conventional treatments of acne were selected and subjected to hormonal assessment. Study Design- This is a descriptive study by assessing various hormonal levels in selected patients. Study Setting- DVL Department, Andhra Medical College affiliated to King George Hospital, Visakhapatnam, Andhra Pradesh, India. RESULTS Out of 25 patients, 12 patients (48%) were in the age group between 15 - 20 years with moderate degree of acne with PCOS, 8 patients (32%) were in the age group between 21 - 25 years, 3 patients (12%) were in the age group between 26 - 30 years and 8% were between 31 - 35 years, and in our study out of 25 patients 56% had hypertriglyceridaemia, 20% with increased free testosterone levels and very few patients with obesity and features of virilisation. CONCLUSION Thus, Hormonal evaluation should not be the last option in treating acne vulgaris and is mandatory not only for more resistant acne cases and for those who fail to respond to conventional therapies, but it also should be done in the beginning even in mild degrees of acne to prevent acne scarring.
Authors and Affiliations
Mohanarao T. S, Chenna Subhashini, Shaik Asha, Swetha Naidu, Anila Sunandini, Guru Prasad, Ch. Naveen Kumar, Chandrasekhar Nalabola
Keywords
Related Articles
- EP ID EP279907
- DOI 10.14260/jemds/2017/1480
- Views 89
- Downloads 0
HENOCH-SCHONLEIN PURPURA - CLINICAL AND INVESTIGATIVE STUDY OF 20 PATIENTS
BACKGROUND Henoch-Schonlein Purpura (HSP) is a systemic small vessel vasculitis with multiorgan involvement characterised by palpable purpura, arthritis, abdominal pain and renal disease. The aetiology and clinical featu...
COMPARATIVE STUDY OF CATHETER DRAINAGE AND NEEDLE ASPIRATION IN THE MANAGEMENT OF LIVER ABSCESS
BACKGROUND The incidence of liver abscess both pyogenic and amoebic is steadily increasing, Liver abscess is potentially curable condition and without treatment the mortality is very high. The objectives of this study we...
PROSPECTIVE STUDY TO COMPARE THE FUNCTIONAL AND COSMETIC OUTCOME OF NEUTRAL SAGITTAL ANORECTOPLASTY (NSARP) VERSUS ANTERIOR SAGITTAL ANORECTOPLASTY (ASARP) IN FEMALE INFANTS WITH VESTIBULAR FISTULA
BACKGROUND Imperforate anus with vestibular fistula is the most common form of anorectal malformation in females. In this anomaly, the development of the sphincteric muscle is usually normal and the fistula or the anus o...
ROLE OF DEFLAZACORT AND TAMSULOSIN IN MEDICAL EXPULSIVE THERAPY FOR SYMPTOMATIC LOWER URETERIC STONES
[b] AIM:[/b] To assess the role of corticosteroid deflazacort in combination with alpha blocker tamsulosin in medical management of symptomatic lower ureteric calculus. [b]INTRODUCTION[/b]: Urinary stone diseas...
COMPARATIVE DIAGNOSTIC STUDY ON BREAST LESIONS
BACKGROUND The aim of the study is to evaluate the breast lumps using ultrasound and mammogram independently and in combination. METHODS In this study group there were 30 patients, out of whom 29 were female an...