Hospital Based Study of Spectrum of Clinical Profile and Outcome of Acute Viral Hepatitis E Infection in Adults: Tip of the Iceberg!
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 6
Abstract
Introduction: Acute hepatitis E is an important cause of acute viral hepatitis (AVH) in adults throughout Asia. It is generally mild and self-limiting and resolves within six weeks. Pregnant women are at increased risk of complications and mortality. There was an outbreak of acute hepatitis E infection in Jamshedpur, Jharkhand due to the faecal contamination of drinking water supply. Hence, a study was undertaken with an aim to evaluate the clinical profile and outcomes of Hepatitis E viral infection in adult patients admitted in Tata Main Hospital (TMH), Jamshedpur. Methods and Materials: A prospective study of 96 adult patients admitted in Tata Main Hospital with jaundice and was IgM anti-HEV positive from April to August 2018 was done. The data analysed included demographic profile, clinical presentation, biochemical parameters, and clinical outcomes. Results: Most common age group affected was 21 to 30 years with male preponderance (M:F-1.6:1). Yellowish discoloration of eyes was the most common symptom (73.9%), followed by fever (42.7%). Hepatomegaly was most common finding on abdominal examination (22.9%). The average ALT and AST levels on presentation were 1894.7U/L (± 1357.3) and 1763.3U/L (± 1397.4) respectively. Most common ultrasound abdomen finding was edematous gall bladder wall (40.6%). Mean duration of hospital stay (LOS) was 6.35 ± 3.87 days. Overall mortality was 1.04%. 14.6% patients had complications. 4.2% women were pregnant and had uneventful outcome. Conclusion: Acute viral hepatitis E is a self-limiting illness. All age groups are affected. Majority of cases are cured with supportive treatment. Mortality is low, despite complications.
Authors and Affiliations
Sangita Kamath, Manish Kumar, Neeraj Jain, Ashok Sunder
Keywords
Related Articles
- EP ID EP532823
- DOI 10.21276/ijmrp.2018.4.6.017
- Views 77
- Downloads 0
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