How do Heterocyclic Amines, Amino Acid Pyrolysates, Inhibit DNA Repair
Journal Title: Advances in Clinical Toxicology - Year 2024, Vol 9, Issue 1
Abstract
Heterocyclic amines (HCAs) and β-carbolines, carcinogenic substances, are produced when amino acids and creatine in food react in a high-temperature environment. Some of them are reported to be rodent carcinogens and potent mutagens and to have co- clastogenic effects by inhibiting the incision step in DNA excision repair. In this study, we studied the mechanisms of their inhibition of DNA excision repair. HCAs (Trp-P- 1, IQ, and Me IQ) suppressed comet responses by UV. Since they were antagonistic to novobiocin that is an inhibitor of ATPase subunit of topoisomerase acting the in the incision step of excision repair and the removal of cyclobutane pyrimidine dimers (CPDs) induced by UV was suppressed by Trp-P-1 and IQ, they were considered to inhibit the incision step of excision repair. On the contrary, β-carbolines (harman and norharman) enhanced comet responses by UV. Since they were antagonistic to cytosine-1-β-D arabinofuranoside that is an inhibitor of DNA polymerase acting in the re-synthesis step of excision repair, they were considered to inhibit the re-synthesis step of excision repair. Based on thesis results, HCAs and β-carbolines were concluded to inhibit the incision and re-synthesis steps of excision repair, respectively.
Authors and Affiliations
Kobayashi R , Sekishita A , Nakamura T , Kawaguchi S and Sasaki YF
Keywords
Related Articles
- EP ID EP754430
- DOI 10.23880/act-16000300
- Views 39
- Downloads 0
Anemia Risk in Relation to Occupational and Environmental Lead Exposure among Inhabitants of Enyigba Lead-Zinc Mining Community in Ebonyi State, Nigeria
Introduction: Environmental and occupational exposure to lead contamination is associated with numerous adverse health effects. This study brought forth the case of anemia risk in relation to occupational and environment...
Evaluation of Synergistic Formulation Extract of Traditional Contraceptive Plants for Acute Oral Toxicity
In folk medicine, certain plants are used to prevent pregnancy. The purpose of the study was to evaluate the synergistic formulation of conventional contraceptive herb’s acute toxicity. Acute toxicity refers to a negativ...
Exploring the Therapeutic Potential of Ougeinia oojeinensis: A Comprehensive Analysis
Ougeinia oojeinensis, a plant indigenous to South Asia, is gaining recognition for its potential therapeutic benefits, particularly in cancer treatment. This study offers a thorough investigation into the phytochemical c...
Radiation/Drug Interactions and the Combinational Effects of Tyrosine Kinase Inhibitors and Radiation Therapy in the Treatment of Cancer
Introduction: Progress in both the development of Tyrosine Kinase Inhibitors (TKIs) and modern radiation therapy (RT) have opened new horizons for the safe and effective treatments of cancer. Combination therapies of TKI...
Toxicological Implications of Hexavalent Chromium in Humans
Heavy metals are quite important as far as industrial production is concerned. This may be attributed to several characteristic properties of the metals which include high strength, durability, high melting and/or boili...