How Noscapine metabolise Heme?
Journal Title: JOURNAL OF ADVANCES IN BIOLOGY - Year 2013, Vol 2, Issue 1
Abstract
Noscapine (NOS) is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin binding, antiangiogenic anticancer drug that cause cell cycle arrest and induces apoptosis in cancer cells both in vitro as well as in vivo. It is a weak base (pKa~7.8) with 44.69 % absolute bioavailability and half-life of 1.33 h by oral route and requires relatively high doses of NOS (ED50~300 mg/kg bwt) for induction of anticancer activity. In the present study, we conducted experiments, wherein, noscapine was administered according to a dose schedule of 5 mg/kg bwt, 10 mg/kg bwt, 20 mg/kg bwt, 50 mg/kg bwt, 100 mg/kg bwt and 250 mg/kg bwt. Glutathione S-Transferase multigene family plays a critical role in the cellular protection. Toxicity evaluation has yielded that noscapine, do not impinge renal or hepatic toxicity at the dosing regimen (5 mg/kg bwt, 10 mg/kg bwt, 20 mg/kg bwt, 50 mg/kg bwt, 100 mg/kg bwt and 150 mg/kg bwt) undertaken during the course of study. Our results depicted that the antioxidant defense system thereby offering cellular protection.
Authors and Affiliations
Prashant Singh, Ramesh Chandra, Harpal Singh, Ankush Chandra, Sujata K. Dass
Keywords
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- EP ID EP654366
- DOI 10.24297/jab.v2i1.1564
- Views 217
- Downloads 0
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