HPA-1 gene polymorphism in Iranian couples with history of recurrent abortion
Journal Title: Khoon - Year 2019, Vol 15, Issue 4
Abstract
HPA-1 gene polymorphism in Iranian couples with history of recurrent abortion Ahmadzadeh Shad Gh.1, Zadsar M.1, Shaiegan M.1, Samiee Sh.1, Zare A.2 1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran 2Sarem Fertility and Infertility Research Center, Sarem Cell Research Center, Sarem Hospital, Tehran, Iran Abstract Background and Objectives Recurrent abortion is referred to a condition that 2 or 3 consecutive pregnancies are affected by abortions before the 20th week of gestation, which is likely to occur in 2-5% of pregnancies. There are some etiologic factors such as anatomical, infectious and immunological elements. One of these immunological factors is the polymorphism of the HPA-1 gene as a factor able to cause FNAIT and its related complications; besides it contributes to abortion as a thrombophilic gene. This study was conducted to evaluate the prevalence of HPA-1 incompatibility in Iranian couples with a history of recurrent abortions. Materials and Methods In this cross-sectional descriptive study, totally 75 couples with at least two recurrent pregnancy losses without any specified causes (according to the medical records obtained from the infertility center) were entered to the study. Four-ml blood samples were collected in EDTA tubes and the allelic frequency of HPA-1 was determined by PCR-SSP. Gene frequency was calculated using the Hardy Weinberg equation. The p< 0.05 was considered significant. Results Totally 75 couples were included with the average age of women being 32 ± 7 years and the mean number of abortions 2.5 ± 0.9. HPA-1a was found in 100% of the under study population, and HPA-1b was absent in this population. Conclusions This study revealed that HPA-1a gene polymorphism does not have the likelihood of being involved in the recurrent abortion in Iranian couples, and other factors need to be investigated to determine the possible causes of recurrent abortion. Key words: Platelets, Abortion، Recurrent, Thrombocytopenia Received: 27 Jun 2018 Accepted:20 Aug 2018 Correspondence: Zadsar M., MD. Pathologist. Assistant Professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine. P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 82052234; Fax: (+9821) 88628741 E-mail: maryam.zad@gmail.com
Authors and Affiliations
Gh. Ahmadzadeh Shad, M. Zadsar, Sh. Samiee, A. Zare
Keywords
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